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In Vitro Suppression of Human Lymphocyte Activity by Minoxidil
Article first published online: 31 MAY 2007
International Journal of Dermatology
Volume 24, Issue 1, pages 249–251, January 1985
How to Cite
Galbraith, G. M. P. and Thiers, B. H. (1985), In Vitro Suppression of Human Lymphocyte Activity by Minoxidil. International Journal of Dermatology, 24: 249–251. doi: 10.1111/j.1365-4362.1985.tb05456.x
- Issue published online: 31 MAY 2007
- Article first published online: 31 MAY 2007
Abstract: The in vitro effect of minoxidil on normal human lymphocyte activity was studied. At a concentration of 0.1 mg/ml, minoxidil significantly inhibited phytohemagglutinin-dependent lymphocyte DNA synthesis (p < 0.05), and at 0.01 mg/ml, 0.05 mg/ml, and 0.1 mg/ml, it suppressed mitogen-dependent production of leukocyte migration inhibition factor (p < 0.04, p < 0.01, and p < 0.01, respectively), without compromising cell viability. Minoxidil thus appears to exert a suppressive effect on normal human T-lymphocytes in vitro. The physiologic relevance of these findings remains uncertain.