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Comparing 2.5%, 5%, and 10% Benzoyl Peroxide on Inflammatory Acne Vulgaris
Article first published online: 31 MAY 2007
DOI: 10.1111/j.1365-4362.1986.tb04534.x
1365-4632/asset/cover.gif?v=1&s=9511fc82959857c05878bdae4be8ee0c51c939f2 "International Journal of Dermatology")
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How to Cite
Mills, O. H., Kligman, A. M., Pochi, P. and Comite, H. (1986), Comparing 2.5%, 5%, and 10% Benzoyl Peroxide on Inflammatory Acne Vulgaris. International Journal of Dermatology, 25: 664–667. doi: 10.1111/j.1365-4362.1986.tb04534.x
Publication History
- Issue published online: 31 MAY 2007
- Article first published online: 31 MAY 2007
- Abstract
- References
- Cited By
ABSTRACT: A 2.5% formulation of benzoyl peroxide was compared with its vehicle, and with a 5% and a 10% proprietary benzoyl peroxide gel preparation in three double-blind studies involving 153 patients with mild to moderately severe acne vulgaris. The 2.5% benzoyl peroxide formulation was more effective than its vehicle and equivalent to the 5% and 10% concentrations in reducing the number of inflammatory lesions (papules and pustules). Desquamation, erythema, and symptoms.of burning with the 2.5% gel were less frequent than with the 10% preparation but equivalent to the 5% gel. The 2.5% formulation also significantly reduced Propionibacterium acnes and the percentage of free fatty acids in the surface lipids after 2 weeks of topical application.