A Speculative on Psoriasis as an Evolutionary Consequence


  • Orville J. Stone M.D.

    Corresponding author
    1. From the Department of Dermatology, University of California at Irvine College of Medicine, Irvine, California
    Search for more papers by this author

Address for correspondence: Orville J. Stone, M.D., 18700 Main Street, #201, Huntington Beach, CA 92649.


I speculate that if the inflammatory reactivity of all humans were quantitated, the results would fall on a bell-shaped curve. Psoriasis or the psoriatic trait is the most reactive 3%. Any attempt by evolution to shift the general inflammatory response to lesser activity would result in consequences more significant than psoriasis. This speculation predicts that we might have to settle for quantitative rather than qualitative changes in inflammation in psoriasis.