CONFLUENT AND RETICULATED PAPILLOMATOSIS: CLINICAL, LIGHT AND ELECTRON MICROSCOPIC STUDIES

Authors

  • MIHOKO JIMBOW M.D., PH.D.,

    Corresponding author
    1. From the Division of Dermatology and Cutaneous Sciences, University of Alberta Faculty of Medicine, Edmonton, Alberta, Canada.
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  • OREST TALPASH M.D., F.R.C.P.C.,

    1. From the Division of Dermatology and Cutaneous Sciences, University of Alberta Faculty of Medicine, Edmonton, Alberta, Canada.
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  • KOWICHI JIMBOW M.D., PH.D., F.R.C.P.C.

    1. From the Division of Dermatology and Cutaneous Sciences, University of Alberta Faculty of Medicine, Edmonton, Alberta, Canada.
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Address for correspondence: Mihoko Jimbow, M.D., Ph.D., Dermatology and Cutaneous Sciences, Faculty of Medicine, 260G Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta, Canada T6G 2S2.

Abstract

A case of a 17-year-old Japanese-Canadian boy with a 2-year history of skin lesions relevant to confluent and reticulated pa-pillomatosis (CRP) is reported with electron microscopic findings. He had scattered skin lesions of brownish-colored, rough-surfaced, fine-scaled patches and plaques distributed on the nape, shoulders, and both flanks, extending to the chest and back. Importantly, they showed reticular or confluent arrangement. There was no family history of the same skin lesions. The histology showed epidermal papillomatosis and mild acanthosis with a marked hyperkeratosis. Electron microscopically, the skin lesions consisted of the following abnormal findings: (1) a marked alteration of cornified cell structures showing snake coil-like, or triangle-like stacks, (2) a marked increase in the number of lamellar granules in the granular layer, (3). an increased number of melanosomes in the horny layers, and (4) no significant fine structural changes of epidermal melanocytes. This is the first electron microscopic report on CRP suggesting that the pathophysiology of this disease is related to abnormal keratinocyte differentiation.

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