TREATMENT OF ROSACEA: TOPICAL CLINDAMYCIN VERSUS ORAL TETRACYCLINE

Authors

  • JONATHAN K. WILKIN M.D.,

    Corresponding author
    1. From the Departments of Medicine and Pharmacology, The Ohio State University, Ohio and the McGuire Veterans Administration Medical Center, Richmond, Virginia.
      Address for correspondence: Jonathan K. Wilkin, M.D., Division of Dermatology, 4731 UHC, 456 W. 10th Avenue, Columbus, OH 43210-1228.
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  • SUELLEN DeWITT R.N., M.S.

    1. From the Departments of Medicine and Pharmacology, The Ohio State University, Ohio and the McGuire Veterans Administration Medical Center, Richmond, Virginia.
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  • Supported by a grant from the Upjohn Company, Kalama-zoo, Michigan.

Address for correspondence: Jonathan K. Wilkin, M.D., Division of Dermatology, 4731 UHC, 456 W. 10th Avenue, Columbus, OH 43210-1228.

Abstract

Background. A new topical antibiotic preparation, clindamycin in a lotion base, was compared with oral tetracycline in the treatment of rosacea. Forty-three patients clinically diagnosed as having rosacea were examined in an investigator-blinded study.

Methods. Patients used topical clindamycin lotion applied twice daily or the usual oral dose of tetracycline hydrochloride (250 mg four times a day for 3 weeks, then 250 mg twice a day for the remaining 9 weeks). Patients’lesions were examined clinically at 3-week intervals over a period of 12 weeks.

Results. Topical clindamycin treatment produced similar clinical results to oral tetracycline and was superior in the eradication of pustules.

Conclusions. These results show topical clindamycin in a lotion base to be a safe and effective alternative to oral tetracycline therapy in the treatment of rosacea.

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