Supported by a grant from the Upjohn Company, Kalama-zoo, Michigan.
TREATMENT OF ROSACEA: TOPICAL CLINDAMYCIN VERSUS ORAL TETRACYCLINE
Article first published online: 31 MAY 2007
International Journal of Dermatology
Volume 32, Issue 1, pages 65–67, January 1993
How to Cite
WILKIN, J. K. and DeWITT, S. (1993), TREATMENT OF ROSACEA: TOPICAL CLINDAMYCIN VERSUS ORAL TETRACYCLINE. International Journal of Dermatology, 32: 65–67. doi: 10.1111/j.1365-4362.1993.tb00974.x
- Issue published online: 31 MAY 2007
- Article first published online: 31 MAY 2007
Background. A new topical antibiotic preparation, clindamycin in a lotion base, was compared with oral tetracycline in the treatment of rosacea. Forty-three patients clinically diagnosed as having rosacea were examined in an investigator-blinded study.
Methods. Patients used topical clindamycin lotion applied twice daily or the usual oral dose of tetracycline hydrochloride (250 mg four times a day for 3 weeks, then 250 mg twice a day for the remaining 9 weeks). Patients’lesions were examined clinically at 3-week intervals over a period of 12 weeks.
Results. Topical clindamycin treatment produced similar clinical results to oral tetracycline and was superior in the eradication of pustules.
Conclusions. These results show topical clindamycin in a lotion base to be a safe and effective alternative to oral tetracycline therapy in the treatment of rosacea.