POST-KALA-AZAR DERMAL LEISHMANIASIS: A CLINICAL AND THERAPEUTIC STUDY
Article first published online: 31 MAY 2007
International Journal of Dermatology
Volume 32, Issue 4, pages 272–275, April 1993
How to Cite
RAMESH, V., MISRA, R. S., SAXENA, U. and MUKHERJEE, A. (1993), POST-KALA-AZAR DERMAL LEISHMANIASIS: A CLINICAL AND THERAPEUTIC STUDY. International Journal of Dermatology, 32: 272–275. doi: 10.1111/j.1365-4362.1993.tb04266.x
- Issue published online: 31 MAY 2007
- Article first published online: 31 MAY 2007
Background. Post-kala-azar dermal leishmaniasis is a condition peculiarly confined to the Indian subcontinent.
Methods. The clinical features and investigations in 18 patients of post-kala-azar dermal leishmaniasis were studied.
Results. There was a polymorphic picture from hypopigmented macules to nodules and plaques. Mucous membranes were affected in five, the lips and glans penis being the most frequent sites, Histopathologically, a rich dermal infiltrate was seen in indurated lesions and in macules; it was confined to perivascular foci in the upper dermis. Leishman-Donovan bodies were seen in 16.
Conclusions. The lesions cleared in 4 to 5 months after treatment with sodium antimony gluconate intramuscularly 20 mg/kg/day up to a maximum of 1 g/day. The drug was well tolerated.