Supported in part by a grant from the Alexander von Humboldt Stiftung and from the Bundesminiserium für Forschung und Technologie (FKZ 01 ZZ 9103/1.12).
IMMUNOLOGIC PARAMETERS IN SYSTEMIC SCLEROSIS
Article first published online: 31 MAY 2007
International Journal of Dermatology
Volume 33, Issue 1, pages 25–32, January 1994
How to Cite
BRUNS, M., HERRMANN, K. and HAUSTEIN, U.-F. (1994), IMMUNOLOGIC PARAMETERS IN SYSTEMIC SCLEROSIS. International Journal of Dermatology, 33: 25–32. doi: 10.1111/j.1365-4362.1994.tb01488.x
- Issue published online: 31 MAY 2007
- Article first published online: 31 MAY 2007
Background. Immunologic abnormalities seem to play an important role in systemic sclerosis (SSc).
Methods. We studied the following immune parameters to get more insight into SSc: autoantibodies (antinuclear antibodies (ana), anti-Scl-70, anticentromere antibodies (aca) subsets of lymphocyte subpopulations and markers of their activation, as well as serum levels of il-2, the soluble il-2 receptor (sil-2r), il-6 and its correlation to N-terminal procollagen-Ill propeptide (piiip), and finally, the il-6 production by SSc and normal dermal fibroblasts.
Results. In patients with active SSc, we found a reduced number of cd2+ T-lymphocytes and an increase in the expression of T-lymphocyte activation markers such as cd25+ and cd71+, hla-dr la, as well as elevated serum levels of sil-2lr and il-6. SSc fibroblasts did not produce more il-6 than normal fibroblasts in monolayer cultures.
Conclusions. Our data show that a wide range of immunologic parameters are altered in SSc. In general, T-helper (th) lymphocytes are activated possibly because of reduced T-suppressor (ts) and natural killer (nk)-cell levels, TH may polyclonally stimulate B cells, which in turn produce higher amounts of autoantibodies. Our findings support the concept that TH cell-derived cytokines/growth factors stimulate matrix protein synthesis by fibroblasts, resulting in generalized fibrosis.