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Seborrheic keratoses: A study comparing the standard cryosurgery with topical calcipotriene, topical tazarotene, and topical imiquimod

Authors


Mark D. Herron, md Department of Dermatology University of Utah Health Sciences Center 30 North 1900 East Salt Lake City Utah 84132 801-581-6465 USA E-mail: address: mherron@derm.med.utah.edu

Abstract

Background  Patients with seborrheic keratoses frequently desire an effective topical therapy for seborrheic keratoses.

Objective  To compare topical calcipotriene, topical tazarotene, and topical imiquimod with standard cryosurgery in the treatment of seborrheic keratoses.

Methods  Fifteen patients with numerous seborrheic keratoses were enrolled in an open-label study comparing cryosurgery with topical agents. Eight separate seborrheic keratoses were selected to be treated with topical medications. One lesion was treated with cryosurgery.

Results  One treatment with cryosurgery led to clinical and histological improvement of all lesions treated. Neither scarring nor recurrence resulted in cryosurgery. In seven of 15 patients, tazarotene 0.1% cream applied BID caused clinical improvement in lesions within 16 weeks.

Conclusion  Cryosurgery produces clinical and histological improvement of seborrheic keratoses. The result with cryosurgery was cosmetically acceptable to all patients. Responders to tazarotene cream 0.1% found it cosmetically acceptable.

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