The authors have no conflict of interest to disclose.
Effect of ethnicity on the risk of developing nonmelanoma skin cancer following long-term PUVA therapy
Article first published online: 22 JUL 2004
International Journal of Dermatology
Volume 44, Issue 12, pages 1016–1021, December 2005
How to Cite
Murase, J. E., Lee, E. E. and Koo, J. (2005), Effect of ethnicity on the risk of developing nonmelanoma skin cancer following long-term PUVA therapy. International Journal of Dermatology, 44: 1016–1021. doi: 10.1111/j.1365-4632.2004.02322.x
- Issue published online: 22 JUL 2004
- Article first published online: 22 JUL 2004
Background Research demonstrating an increased incidence of skin cancer with psoralen plus ultraviolet A (PUVA) therapy has reflected the Caucasian experience. Our objective was to review the literature on skin cancer risk associated with long-term PUVA therapy in non-Caucasians.
Methods Our analysis included 4294 long-term PUVA patients in Japan, Korea, Thailand, Egypt, and Tunisia with a follow-up period of at least 5 years.
Results The relative risk of PUVA patients developing nonmelanoma skin cancer relative to general dermatology outpatients was 0.86 [CI 0.36–1.35].
Conclusions There does not appear to be an increased risk of nonmelanoma skin cancer with long-term PUVA therapy in Asian and Arabian-African populations. Therefore, in phototherapy risk assessment, it is important to consider the patient's skin phototype and the potential protection that more pigmented skin may confer.