Influence of desloratadine on oxidative stress markers in patients with chronic idiopathic urticaria

Authors

  • Nicoletta Cassano MD,

    1. From the Istituto Dermopatico dell’Immacolata, I.D.I., I.R.C.C.S., Rome, the Department of Medical Biochemistry and Biology, University of Bari, and the 2nd Unit of Dermatology, MIDIM Department, University of Bari, Italy
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  • Gabriella Raho MD,

    1. From the Istituto Dermopatico dell’Immacolata, I.D.I., I.R.C.C.S., Rome, the Department of Medical Biochemistry and Biology, University of Bari, and the 2nd Unit of Dermatology, MIDIM Department, University of Bari, Italy
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  • Maura Filieri MD,

    1. From the Istituto Dermopatico dell’Immacolata, I.D.I., I.R.C.C.S., Rome, the Department of Medical Biochemistry and Biology, University of Bari, and the 2nd Unit of Dermatology, MIDIM Department, University of Bari, Italy
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  • Vito D’Argento MD,

    1. From the Istituto Dermopatico dell’Immacolata, I.D.I., I.R.C.C.S., Rome, the Department of Medical Biochemistry and Biology, University of Bari, and the 2nd Unit of Dermatology, MIDIM Department, University of Bari, Italy
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  • Antonella Amoruso MD,

    1. From the Istituto Dermopatico dell’Immacolata, I.D.I., I.R.C.C.S., Rome, the Department of Medical Biochemistry and Biology, University of Bari, and the 2nd Unit of Dermatology, MIDIM Department, University of Bari, Italy
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  • Raffaele Filotico MD,

    1. From the Istituto Dermopatico dell’Immacolata, I.D.I., I.R.C.C.S., Rome, the Department of Medical Biochemistry and Biology, University of Bari, and the 2nd Unit of Dermatology, MIDIM Department, University of Bari, Italy
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  • Gino A. Vena MD

    1. From the Istituto Dermopatico dell’Immacolata, I.D.I., I.R.C.C.S., Rome, the Department of Medical Biochemistry and Biology, University of Bari, and the 2nd Unit of Dermatology, MIDIM Department, University of Bari, Italy
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  • The authors declare no financial involvement or interest in the subject matter discussed in the manuscript. They also declare that the manuscript has been submitted exclusively to the International Journal of Dermatology.

Prof. Gino A. Vena, md 2nd Unit of Dermatology M.I.D.I.M. Department University of Bari Policlinico Piazza Giulio Cesare, 11 70124 Bari Italy E-mail: g.vena@dermatologia.uniba.it

Abstract

Background  Recent findings suggest the involvement of oxidative stress in the pathogenesis of chronic idiopathic urticaria (CIU). It has been demonstrated that desloratadine has an antioxidant activity in vitro. We evaluated the effects of desloratadine on markers of oxidative stress in patients with CIU.

Methods  Blood samples were obtained from 10 patients with CIU before and after 4 weeks of treatment with desloratadine. Blood samples from 10 healthy volunteers were used as controls. In platelets from both patients and controls, radical oxygen species (ROS) production was measured using spectrofluorimetric detection of dichloro-fluorescein oxidation, and superoxide dismutase (SOD) activity was determined by means of the xanthine-xanthine oxidase system.

Results  Radical oxygen species concentrations and SOD activity were significantly elevated in patients with CIU at baseline as compared with control subjects. Treatment with desloratadine caused a relevant reduction of ROS levels and SOD activity (P < 0.005).

Conclusions  These preliminary results suggest that desloratadine exerts antioxidant effects also in vivo.

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