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Seroprevalence of HHV-8 infection in the pediatric population of two university hospitals in Rio de Janeiro, Brazil

Authors

  • João Carlos Regazzi Avelleira MD,

    1. From the Department of Medical Clinics (Dermatology), Universidade Federal do Rio de Janeiro, Rio de Janeiro, and the Seção de Imunologia, Instituto Adolfo Lutz de São Paulo, Brazil
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  • Omar Lupi MD, PhD,

    1. From the Department of Medical Clinics (Dermatology), Universidade Federal do Rio de Janeiro, Rio de Janeiro, and the Seção de Imunologia, Instituto Adolfo Lutz de São Paulo, Brazil
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  • Adele Caterino-de-Araujo PhD,

    1. From the Department of Medical Clinics (Dermatology), Universidade Federal do Rio de Janeiro, Rio de Janeiro, and the Seção de Imunologia, Instituto Adolfo Lutz de São Paulo, Brazil
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  • Elizabeth de los Santos-Fortuna MSC

    1. From the Department of Medical Clinics (Dermatology), Universidade Federal do Rio de Janeiro, Rio de Janeiro, and the Seção de Imunologia, Instituto Adolfo Lutz de São Paulo, Brazil
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  • This paper was approved by the Ethics Committee on research of the participating hospitals, assuring the patients confidentiality of the obtained results.

João Carlos Regazzi Avelleira Rua Diamantina 20/101 Rio de Janeiro RJ Brazil CEP: 22465–150 E-mail: avelleira@unikey.com.br

Abstract

Background  The authors present a serologic survey of the prevalence of herpesvirus-8 (HHV-8) among 171 children from 0 to 12 years old in Rio de Janeiro, Brazil.

Materials and methods  Sera were tested for latent nuclear and lytic antigens using indirect immunofluorescence and Western blotting.

Results  Serology for HHV-8 was positive in 16 of 171 patients (9.35%). Among 13 HIV-positive patients, four (31%) were also positive for HHV-8. The seropositivity among healthy children was 7.6%, and females were significantly (P < 0.002) more associated with HHV-8 seropositivity (16%) than males (1.1%).

Conclusions  We detected a higher HHV-8 seroprevalence among the pediatric population in Rio de Janeiro, Brazil, when compared with similar studies performed in other countries. Nonsexual routes of transmission are a possible explanation for this pattern. The unusual finding of a higher seroprevalence among female children could be explained by a specific route of exposition or even an epidemiological bias.

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