Cutaneous T-cell lymphoma with HTLV-I infection: clinical overlap with adult T-cell leukemia/lymphoma

Authors

  • F. H. Sakamoto MD,

    1. From the Department of Dermatology, Discipline of Hematology and Hemotherapy, Department of Pathology, Universidade Federal de São Paulo – Escola Paulista de Medicina (UNIFESP/EPM), São Paulo, and Centro de Pesquisas-Instituto Nacional do Câncer, Divisão de Medicina Experimental, Rio de Janeiro, Brazil
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  • G. W. B Colleoni MD, PhD,

    1. From the Department of Dermatology, Discipline of Hematology and Hemotherapy, Department of Pathology, Universidade Federal de São Paulo – Escola Paulista de Medicina (UNIFESP/EPM), São Paulo, and Centro de Pesquisas-Instituto Nacional do Câncer, Divisão de Medicina Experimental, Rio de Janeiro, Brazil
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  • S. P. Teixeira MD,

    1. From the Department of Dermatology, Discipline of Hematology and Hemotherapy, Department of Pathology, Universidade Federal de São Paulo – Escola Paulista de Medicina (UNIFESP/EPM), São Paulo, and Centro de Pesquisas-Instituto Nacional do Câncer, Divisão de Medicina Experimental, Rio de Janeiro, Brazil
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  • M. Yamamoto MD, PhD,

    1. From the Department of Dermatology, Discipline of Hematology and Hemotherapy, Department of Pathology, Universidade Federal de São Paulo – Escola Paulista de Medicina (UNIFESP/EPM), São Paulo, and Centro de Pesquisas-Instituto Nacional do Câncer, Divisão de Medicina Experimental, Rio de Janeiro, Brazil
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  • N. S. Michalany MD, PhD,

    1. From the Department of Dermatology, Discipline of Hematology and Hemotherapy, Department of Pathology, Universidade Federal de São Paulo – Escola Paulista de Medicina (UNIFESP/EPM), São Paulo, and Centro de Pesquisas-Instituto Nacional do Câncer, Divisão de Medicina Experimental, Rio de Janeiro, Brazil
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  • F. A. Almeida MD, PhD,

    1. From the Department of Dermatology, Discipline of Hematology and Hemotherapy, Department of Pathology, Universidade Federal de São Paulo – Escola Paulista de Medicina (UNIFESP/EPM), São Paulo, and Centro de Pesquisas-Instituto Nacional do Câncer, Divisão de Medicina Experimental, Rio de Janeiro, Brazil
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  • A. K. Chiba MSc,

    1. From the Department of Dermatology, Discipline of Hematology and Hemotherapy, Department of Pathology, Universidade Federal de São Paulo – Escola Paulista de Medicina (UNIFESP/EPM), São Paulo, and Centro de Pesquisas-Instituto Nacional do Câncer, Divisão de Medicina Experimental, Rio de Janeiro, Brazil
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  • V. Petri MD, PhD,

    1. From the Department of Dermatology, Discipline of Hematology and Hemotherapy, Department of Pathology, Universidade Federal de São Paulo – Escola Paulista de Medicina (UNIFESP/EPM), São Paulo, and Centro de Pesquisas-Instituto Nacional do Câncer, Divisão de Medicina Experimental, Rio de Janeiro, Brazil
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  • M. A. Fernandes MSc,

    1. From the Department of Dermatology, Discipline of Hematology and Hemotherapy, Department of Pathology, Universidade Federal de São Paulo – Escola Paulista de Medicina (UNIFESP/EPM), São Paulo, and Centro de Pesquisas-Instituto Nacional do Câncer, Divisão de Medicina Experimental, Rio de Janeiro, Brazil
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  • M. S. Pombo-de-Oliveira MD, PhD

    1. From the Department of Dermatology, Discipline of Hematology and Hemotherapy, Department of Pathology, Universidade Federal de São Paulo – Escola Paulista de Medicina (UNIFESP/EPM), São Paulo, and Centro de Pesquisas-Instituto Nacional do Câncer, Divisão de Medicina Experimental, Rio de Janeiro, Brazil
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Gisele Colleoni Rua Botucatu, 740 3° andar Hematologia CEP 043900–000 Vila Clementino São Paulo SP, Brazil E-mail: gcolleoni@hemato.epm.br

Abstract

Adult T-cell leukemia/lymphoma (ATLL) is a malignant proliferation of mature helper T lymphocytes,1 and is caused by human T-lymphotropic virus type I (HTLV-I);2 an HTLV-I infection endemic in the Caribbean, south-western Japan, South America and Africa.3,4 Seroepidemiological studies suggest that it is also endemic in Brazil.5 Although carriers of HTLV-I show polyclonal integration of virus in T lymphocytes, only patients with ATLL of various subtypes show monoclonal integration of HTLV-I in tumor cells.6,7 Cutaneous T-cell lymphomas (CTCL) are a group of primary cutaneous lymphoproliferative diseases8 with unknown etiology.9 The two most common presentations of CTCL are mycosis fungoides (MF) and Sézary syndrome (SS).10–13 However, both CTCL categories can easily resemble ATLL. Therefore, in HTLV-I endemic areas, differentiation between ATLL and CTCL must be performed, as they have different prognoses and treatment approaches.14

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