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Pemphigus vulgaris and pemphigus foliaceus: similar prognosis?

Authors

  • I. Zaraa MD,

    1. From the Department of Dermatology, La Rabta Hospital, Jabbari, Department of Preventive Medicine and Public Health, The National Public Health Institute, Department of Anatomopathology, Pasteur Institute, and Department of Immunology, La Rabta Hospital, Jabbari, Tunis, Tunisia
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  • M. Mokni MD,

    1. From the Department of Dermatology, La Rabta Hospital, Jabbari, Department of Preventive Medicine and Public Health, The National Public Health Institute, Department of Anatomopathology, Pasteur Institute, and Department of Immunology, La Rabta Hospital, Jabbari, Tunis, Tunisia
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  • M. Hsairi MD,

    1. From the Department of Dermatology, La Rabta Hospital, Jabbari, Department of Preventive Medicine and Public Health, The National Public Health Institute, Department of Anatomopathology, Pasteur Institute, and Department of Immunology, La Rabta Hospital, Jabbari, Tunis, Tunisia
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  • S. Boubaker MD,

    1. From the Department of Dermatology, La Rabta Hospital, Jabbari, Department of Preventive Medicine and Public Health, The National Public Health Institute, Department of Anatomopathology, Pasteur Institute, and Department of Immunology, La Rabta Hospital, Jabbari, Tunis, Tunisia
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  • M. Sellami MD,

    1. From the Department of Dermatology, La Rabta Hospital, Jabbari, Department of Preventive Medicine and Public Health, The National Public Health Institute, Department of Anatomopathology, Pasteur Institute, and Department of Immunology, La Rabta Hospital, Jabbari, Tunis, Tunisia
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  • M. Zitouni MD,

    1. From the Department of Dermatology, La Rabta Hospital, Jabbari, Department of Preventive Medicine and Public Health, The National Public Health Institute, Department of Anatomopathology, Pasteur Institute, and Department of Immunology, La Rabta Hospital, Jabbari, Tunis, Tunisia
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  • S. Makni MD,

    1. From the Department of Dermatology, La Rabta Hospital, Jabbari, Department of Preventive Medicine and Public Health, The National Public Health Institute, Department of Anatomopathology, Pasteur Institute, and Department of Immunology, La Rabta Hospital, Jabbari, Tunis, Tunisia
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  • A. Ben Osman Dhahri MD

    1. From the Department of Dermatology, La Rabta Hospital, Jabbari, Department of Preventive Medicine and Public Health, The National Public Health Institute, Department of Anatomopathology, Pasteur Institute, and Department of Immunology, La Rabta Hospital, Jabbari, Tunis, Tunisia
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Mourad Mokni, MD Department of Dermatology La Rabta Hospital Jabbari Bab Saadoun 1007 Tunis Tunisia E-mail: mourad.mokni@rns.tn

Abstract

Background  Pemphigus is a rare, life-threatening, acquired autoimmune bullous dermatosis. The prognosis of pemphigus foliaceus (PF) is usually regarded as more favourable than that of pemphigus vulgaris (PV). Our study aims to compare the clinical course of PV and PF in 37 patients.

Patients and Methods  We conducted a retrospective study over a period of eight years (1994–2001). The patients were referred during this period and were followed until December 2003. PF and PV were included based on clinical, histological and immunopathological criteria.

Results  In our study there was no significant difference between PF group and PV group concerning; age, sex, duration of the disease, presence of disseminated lesions, treatment, healing time, remission, relapse, complications, death and follows up duration. The survival graph showed no difference between the two groups for the first two relapses. There was a tendency to significance concerning an additional treatment and relapses frequency in the PF group.

Conclusions  Few studies in the literature were interested in the evolution of the two forms of pemphigus. They showed that the two populations share the same clinical course; nevertheless they revealed the frequency of partial remission, failed treatment, relapses, necessity of high dose of corticosteroids, and difficulties of discontinuing treatment in PF. Our study, suggests that PF and PV may share the same clinical course.

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