Is nitric oxide involved in the pathophysiology of essential hyperhidrosis?

Authors

  • Semsettin Karaca MD,

    1. From the Department of Dermatology, School of Medicine, Afyon Kocatepe University, Afyon, Department of Medical Biology, School of Medicine, Suleyman Demirel University, Isparta, and Department of Cardiology, Kosuyolu Heart Education and Research Hospital, Istanbul, Turkey
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  • Mustafa Kulac,

    1. From the Department of Dermatology, School of Medicine, Afyon Kocatepe University, Afyon, Department of Medical Biology, School of Medicine, Suleyman Demirel University, Isparta, and Department of Cardiology, Kosuyolu Heart Education and Research Hospital, Istanbul, Turkey
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  • Efkan Uz,

    1. From the Department of Dermatology, School of Medicine, Afyon Kocatepe University, Afyon, Department of Medical Biology, School of Medicine, Suleyman Demirel University, Isparta, and Department of Cardiology, Kosuyolu Heart Education and Research Hospital, Istanbul, Turkey
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  • Irfan Barutcu,

    1. From the Department of Dermatology, School of Medicine, Afyon Kocatepe University, Afyon, Department of Medical Biology, School of Medicine, Suleyman Demirel University, Isparta, and Department of Cardiology, Kosuyolu Heart Education and Research Hospital, Istanbul, Turkey
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  • H. Ramazan Yilmaz

    1. From the Department of Dermatology, School of Medicine, Afyon Kocatepe University, Afyon, Department of Medical Biology, School of Medicine, Suleyman Demirel University, Isparta, and Department of Cardiology, Kosuyolu Heart Education and Research Hospital, Istanbul, Turkey
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Semsettin Karaca, md Afyon Kocatepe Universitesi Ahmet Necdet Sezer Uygulama ve Arastırma Hastanesi Dermatoloji Klinigi (Pembe Hastane) Afyon Turkey E-mail: skaraca@aku.edu.tr; shems@hotmail.com

Abstract

Background  Essential hyperhidrosis (EH) is a disorder of excessive, bilateral, and relatively symmetric sweating occurring in the axillae, palms, soles, or craniofacial region without obvious etiology. The expression of endothelial nitric oxide synthase (eNOS) in eccrine clear cells, reported by an immunohistochemical technique, has suggested that nitric oxide (NO) may play a role in the physiology of production and/or excretion of sweat in the human skin eccrine gland.

Aim  To determine plasma NO levels in patients with EH and healthy controls.

Methods  We assessed the levels of plasma NO in patients with EH (n = 31) in comparison with those in age- and sex-matched healthy controls (n = 28). Total nitrite (nitrite + nitrate) was measured by a spectrophotometer at 545 nm after the conversion of nitrate to nitrite by copperized cadmium granules.

Results  Plasma NO levels were found to be significantly increased in EH patients in comparison with the control group (P = 0.0001).

Conclusions  These findings indicate a possible role of increased plasma NO levels in the pathophysiology of EH.

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