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Olmsted syndrome: a case report and review of literature

Authors

  • Juan Tao,

    1. From 1Department of Dermatology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China,
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    • *

      These authors contributed equally to this work.

  • Chang-zheng Huang,

    1. From 1Department of Dermatology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China,
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    • *

      These authors contributed equally to this work.

  • Nian-wen Yu,

    1. 2Department of Dermatology, Affiliated Huiji Hospital of Hubei Professional and Technology College, Xiaogan, Hubei 432000, China, and
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  • Yan Wu,

    1. From 1Department of Dermatology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China,
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  • Ye-qiang Liu,

    1. From 1Department of Dermatology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China,
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  • Yan Li,

    1. From 1Department of Dermatology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China,
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  • Jin Tian,

    1. From 1Department of Dermatology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China,
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  • Ling-yun Yang,

    1. From 1Department of Dermatology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China,
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  • Jing Zhang,

    1. From 1Department of Dermatology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China,
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  • Jia-wen Li,

    1. From 1Department of Dermatology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China,
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  • You-wen Zhou,

    1. 3Department of Dermatology and Skin Science, University of British Columbia, Vancouver, Canada
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  • Ya-ting Tu

    1. From 1Department of Dermatology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China,
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Tu Ya-ting and Huang Chang-zheng Department of Dermatology Affiliated Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan, 430022 China
E-mail: tjhappy@126.com; hcz0501@126.com

Abstract

We report a case of an 18-month-old boy with slightly whitened fingernails and toenails since birth. At the age of 100 days, he progressively developed bilateral palmoplantar keratoderma which resulted in painful walking and disabled grasping. Perianal keratotic plaques and perioral hyperkeratotic erythema could also be observed. Both fingernails and toenails were dystrophic. Scalp hairs were sparse, but total alopecia was no present. The histopathologic changes of the biopsy from the inner side of the right foot showed nonspecific changes, which mainly showed highly hyperkeratosis and acanthosis with slight superficial perivascular inflammatory infiltration. A clinical diagnosis of Olmsted syndrome was established according to the typical feature of the lesions, which is the presence of symmetrical palmoplantar keratoderma with periorificial keratotic plaques. We review the literature and present a summary of all reported cases to date.

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