Lichen striatus in adults and pimecrolimus: open, off-label clinical study

Authors

  • Anna Campanati MD,

    1. From the Department of Dermatology and Institute of Anatomopathology, Faculty of Medicine, Marche Polytechnic University, Ancona, Italy
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  • Giuliano Brandozzi MD,

    1. From the Department of Dermatology and Institute of Anatomopathology, Faculty of Medicine, Marche Polytechnic University, Ancona, Italy
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  • Mirella Giangiacomi MD,

    1. From the Department of Dermatology and Institute of Anatomopathology, Faculty of Medicine, Marche Polytechnic University, Ancona, Italy
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  • Oriana Simonetti MD,

    1. From the Department of Dermatology and Institute of Anatomopathology, Faculty of Medicine, Marche Polytechnic University, Ancona, Italy
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  • Barbara Marconi MD,

    1. From the Department of Dermatology and Institute of Anatomopathology, Faculty of Medicine, Marche Polytechnic University, Ancona, Italy
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  • Anna Maria Offidani

    1. From the Department of Dermatology and Institute of Anatomopathology, Faculty of Medicine, Marche Polytechnic University, Ancona, Italy
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Anna Campanati, MD Department of Dermatology Marche Polytechnic University Ospedale Torrette Via Conca 71 60200 Ancona Italy
E-mail: a.campanati@ao-umbertoprimo.marche.it

Abstract

Background  Lichen striatus is a well-known, acquired, self-healing, linear inflammatory dermatosis. Lichen striatus occurring in adults tends to be more extensive and itchy than in children, sometimes requiring symptomatic treatment. The therapeutic approach usually adopted is topical steroids, even though prolonged use may lead to several side-effects, particularly cutaneous atrophy.

Objective  To report the results of an open, off-label study on the use of pimecrolimus 1% in the treatment of diffuse, nonresponsive forms of lichen striatus.

Methods  Three adult patients suffering from relapsing or disseminated and itchy lichen striatus received topical application of pimecrolimus 1% cream (Elidel®, Novartis Pharma, Basle, Switzerland) twice daily for 6 weeks, or until complete disappearance of the cutaneous lesions.

Results  All patients experienced rapid healing of the dermatosis, without any recurrence for at least 14 months.

Conclusion  Our preliminary results show that pimecrolimus may represent a useful therapeutic alternative for lichen striatus, although further studies on a larger number of cases are needed to confirm its safety and efficacy in the treatment of this condition.

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