Comparison of depression, anxiety and life quality in acne vulgaris patients who were treated with either isotretinoin or topical agents

Authors

  • Yesim Kaymak MD,

    1. From the Dermatology Specialist, University of Gazi, Health Center, Gaza, Palestine, Psychiatry Specialist, University of Gazi, Health Center, Gaza, Palestine, and Child and Adolescent Psychiatry Specialist, University of Ufuk, Faculty of Medicine, Department of Child and Adolescent Psychiatry, Ankara, Turkey
    Search for more papers by this author
  • Ender Taner MD,

    1. From the Dermatology Specialist, University of Gazi, Health Center, Gaza, Palestine, Psychiatry Specialist, University of Gazi, Health Center, Gaza, Palestine, and Child and Adolescent Psychiatry Specialist, University of Ufuk, Faculty of Medicine, Department of Child and Adolescent Psychiatry, Ankara, Turkey
    Search for more papers by this author
  • Yasemen Taner MD

    1. From the Dermatology Specialist, University of Gazi, Health Center, Gaza, Palestine, Psychiatry Specialist, University of Gazi, Health Center, Gaza, Palestine, and Child and Adolescent Psychiatry Specialist, University of Ufuk, Faculty of Medicine, Department of Child and Adolescent Psychiatry, Ankara, Turkey
    Search for more papers by this author


Yeşim Kaymak, MD
Hoşdere cad. şair Baki Sok. 2/5 Y Ayranci-Ankara 06540, Turkey
E-mail: yesimkaymak@yahoo.com

Abstract

Background  Since the introduction of isotretinoin to the market, many adverse psychiatric effects, including depression, anxiety and suicide attempts were reported. The aim of this study was to determine whether patients with acne who were treated with isotretinoin experienced significant increases in psychiatric symptoms over a 4-month period compared with patients who received topical acne therapy.

Methods  Seventy-eight acne patients were allocated either to isotretinoin treatment (study group) (n = 37) or to topical treatment (control group) (n = 41). Their psychological status was evaluated at the baseline, second and fourth months of the treatment. All patients were required to complete the dermatology life quality index (DLQI), the Hospital anxiety and depression (HAD) scale, and the beck depression inventory (BDI).

Results  The two groups were not different from each other in terms of DLQI, BDI, HAD-A, HAD-D and total HAD scores at baseline. However, at the end of the second month quality of life was more impaired in the topical treatment group compared to the isotretinoin group (P < 0.05), and there were no difference between two groups in terms of BDI, HAD-A, HAD-D, and total HAD scores (P > 0.05). At the end of fourth month quality of life and all psychological test scores had improved more in the isotretinoin group compared to topical treatment group (P < 0.05).

Conclusion  Results of the present study indicate that there is no increase in depressive and anxiety symptoms in the isotretinoin treatment group compared to that in the topical group. Instead, successful treatment of acne seems to improve both depressive and anxiety symptoms and improve quality of life.

Ancillary