Acute generalized exanthematous pustulosis: report of 12 cases and literature review

Authors

  • Elizabeth Guevara-Gutierrez MD,

    1. From the Instituto Dermatológico de Jalisco, Secretaría de Salud Jalisco, Guadalajara, Hospital General de Occidente, Secretaría de Salud Jalisco, Zapopan, and UMAE Hospital de Pediatría CMNO, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico
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  • Elia Uribe-Jimenez MD,

    1. From the Instituto Dermatológico de Jalisco, Secretaría de Salud Jalisco, Guadalajara, Hospital General de Occidente, Secretaría de Salud Jalisco, Zapopan, and UMAE Hospital de Pediatría CMNO, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico
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  • Margarita Diaz-Canchola MD,

    1. From the Instituto Dermatológico de Jalisco, Secretaría de Salud Jalisco, Guadalajara, Hospital General de Occidente, Secretaría de Salud Jalisco, Zapopan, and UMAE Hospital de Pediatría CMNO, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico
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  • Alberto Tlacuilo-Parra MD, MSc

    1. From the Instituto Dermatológico de Jalisco, Secretaría de Salud Jalisco, Guadalajara, Hospital General de Occidente, Secretaría de Salud Jalisco, Zapopan, and UMAE Hospital de Pediatría CMNO, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico
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Elizabeth Guevara-Gutiérrez, MD Monte Olimpo Núm. 1413 Colonia Independencia CP 44340 Guadalajara Jalisco Mexico
E-mail: albtlacuilo@yahoo.com

Abstract

Background  Acute generalized exanthematous pustulosis is an acute pustular eruption occurring after infection and/or drug ingestion, with spontaneous cure after a single eruption.

Aim  To communicate a series of cases of acute generalized exanthematous pustulosis.

Methods  A retrospective analysis was performed on cases of acute generalized exanthematous pustulosis, observed between 1993 and 2006 at the Dermatology Department, Hospital General de Occidente, Jalisco, Mexico.

Results  Twelve patients were included, with a predominance of male patients and a mean age of 28 years. The most common cause was drugs, detected in 83% of cases, and most of these were a result of anticonvulsants and antimicobials. The most frequent symptoms were itching, present in all cases, and fever, present in 92% of cases.

Conclusions  Acute generalized exanthematous pustulosis is considered to be a distinct clinical and histopathologic entity. Because of its self-resolving character, early recognition can help to avoid unnecessary diagnostic studies and treatments.

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