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Marked elevation of serum macrophage migration inhibitory factor levels in patients with pemphigus vulgaris

Authors

  • Mohammad Reza Namazi MD,

    1. Dermatology Department, Shiraz University of Medical Sciences, Shiraz, Iran
    2. Autoimmune Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
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  • Mohammad Kazem Fallahzadeh MD,

    1. Dermatology Department, Shiraz University of Medical Sciences, Shiraz, Iran
    2. Autoimmune Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
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  • Hassan Shaghelani MD,

    1. Dermatology Department, Shiraz University of Medical Sciences, Shiraz, Iran
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  • Eskandar Kamali-Sarvestani PhD

    1. Autoimmune Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
    2. Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran
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Dr Mohammad Kazem Fallahzadeh
Dermatology Department
Faghihi Hospital
Shiraz
Iran
E-mail: kazem.fa@gmail.com

Abstract

Background  There is ample evidence for involvement of macrophage migration inhibitory factor (MIF) in autoimmune and inflammatory diseases.

Objective  The aim of this study was to determine whether MIF levels were raised in the sera of patients with pemphigus vulgaris (PV).

Methods  Serum MIF levels were measured using ELISA method in 22 patients with active PV and 21 age- and sex-matched healthy controls and the results were compared with each other.

Results  The mean serum MIF levels was significantly higher in PV patients than in control subjects (11.99 ± 1.63 pg/m vs. 1.83 ± 0.22 pg/ml; P-value = 0.0001).

Conclusions  Elevated MIF levels in the sera of PV patients could participate in disease induction by activation of T cells as well as induction of autoantibody production by B cells. Given that MIF counter-regulates the effects of steroids, MIF antagonists may prove to be very effective, novel steroid-sparing agents for this life-threatening conundrum.

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