Background  Systemic glucocorticoids are used in dermatologic practice for various diseases including connective tissue disorders, bullous diseases, and many other dermatologic conditions. Patients with these diseases are at times treated with long-term courses of glucocorticoids, which place them at increased risk for glucocorticoid-induced side effects. Therefore, dermatologists must be knowledgeable of risks related to glucocorticoid use and be familiar with guidelines to manage them.

Objective  To provide an update of recent advances in the prevention and treatment of major glucocorticoid-induced side effects.

Methods  Review of the literature Results Data regarding the prevention and treatment of glucocorticoid-induced side effects are presented.

Conclusion  This review should help dermatologists optimally manage and prevent glucocorticoid-induced side effects.