Positivity for HLA DR1 is associated with basal cell carcinoma in renal transplant patients in southern Brazil

Authors

  • André V. E. de Carvalho MD,

    1. Department of Dermatology, Complexo Hospitalar Santa Casa de Porto Alegre (Santa Casa Hospital Complex, Porto Alegre)
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  • Renan R. Bonamigo MD, PhD,

    1. Postgraduate Program of Pathology
    2. Department of Dermatology
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  • Cristina M. da Silva MD,

    1. Faculty of Medicine, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA, Health Sciences State University of Porto Alegre), Porto Alegre, RS, Brazil
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  • Ângela C. De Zorzi Pinto MD

    1. Faculty of Medicine, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA, Health Sciences State University of Porto Alegre), Porto Alegre, RS, Brazil
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  • Funding: This study was sponsored by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Brazil.

  • Conflicts of interest: None.

André Vicente Esteves de Carvalho, MD
Rua Ramiro Barcelos
1172, sl. 218
90035-002 Porto Alegre
RS Brazil
E-mail: avecarvalho@me.com

Abstract

Background  Renal transplant patients have a higher incidence of non-melanoma skin cancer (NMSC). Previous studies hypothesized that human leukocyte antigen (HLA), especially types DR1, DR4, and DR7, may influence the incidence of these tumors. This study investigates the association between NMSC and the presence of HLA DR1, DR4, and DR7 in renal transplant patients in southern Brazil.

Methods  In a historical cohort study, 1032 patients who underwent renal transplantation during the period from January 1993 to December 2006 were examined to identify occurrences of NMSC and HLA status prior to transplant.

Results  Of the 1032 patients examined, 59 (5.71%) developed NMSC (squamous cell carcinoma [SCC]: 2.42%; basal cell carcinoma [BCC]: 1.74%; both: 1.55%). The presence of HLA DR1 was associated with a higher probability of developing any NMSC and particularly with developing BCC (P < 0.05). There was no statistically significant association between the presence of HLA DR4 or DR7 and the occurrence of NMSC in this sample.

Conclusions  HLA DR1 appears to be associated with the development of BCC, as well as with the higher number of NMSC lesions in renal transplant patients. This study supports the trend to associate the DR1 allele with BCC and not with SCC.

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