Funding sources: None.
Linear IgA bullous dermatosis: report of five cases in Chile
Article first published online: 16 OCT 2012
© 2012 The International Society of Dermatology
International Journal of Dermatology
Volume 51, Issue 11, pages 1303–1306, November 2012
How to Cite
Sandoval, M., Farias, M. M. and Gonzalez, S. (2012), Linear IgA bullous dermatosis: report of five cases in Chile. International Journal of Dermatology, 51: 1303–1306. doi: 10.1111/j.1365-4632.2011.05324.x
Conflicts of interest: None.
- Issue published online: 16 OCT 2012
- Article first published online: 16 OCT 2012
Background Linear IgA bullous dermatosis (LABD) is an acquired autoimmune sub-epidermal vesiculobullous disease characterized by continuous linear IgA deposit on the basement membrane zone, as visualized on direct immunofluorescence microscopy. LABD can affect both adults and children. The disease is very uncommon, with a still unknown incidence in the South American population.
Materials and methods All confirmed cases of LABD by histological and immunofluorescence in our hospital were studied.
Results The confirmed cases were three females and two males, aged from 8 to 87 years. Precipitant events associated with LABD were drug consumption (non-steroid inflammatory agents in two cases) and ulcerative colitis (one case). Most of our patients were treated with dapsone, resulting in remission.
Discussion Our series confirms the heterogeneous clinical features of this uncommon disease in concordance with a larger series of patients reported in the literature.