Funding: This study was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs, South Korea (A090180).
Pharmacology and therapeutics
Transdermal drug delivery using disk microneedle rollers in a hairless rat model
Article first published online: 20 JUN 2012
© 2012 The International Society of Dermatology
International Journal of Dermatology
Volume 51, Issue 7, pages 859–863, July 2012
How to Cite
Kim, H. M., Lim, Y. Y., An, J.-H., Kim, M. N. and Kim, B. J. (2012), Transdermal drug delivery using disk microneedle rollers in a hairless rat model. International Journal of Dermatology, 51: 859–863. doi: 10.1111/j.1365-4632.2011.05343.x
Conflicts of interest: None.
- Issue published online: 20 JUN 2012
- Article first published online: 20 JUN 2012
Background Transdermal drug delivery systems (TDDSs) represent more reliable and consistent methods of drug dosing than oral administration. However, TDDSs can administer only low molecular weight (MW) drugs and require a power source. Disk microneedle rollers facilitate the passage of low and high MW substances through the direct perforation of the stratum corneum and dermis, without stimulating dermal nerves.
Objectives We investigated in vitro whether disk microneedle rollers, developed for the Diskneedle Therapy System (DTS™) in South Korea, can deliver drugs effectively through the skin of hairless rats.
Methods The disk microneedle rollers used in the DTS™ are metal and consist of several plates bearing microneedles of graded lengths (0.15 mm, 0.25 mm, 0.50 mm). To test in vitro permeation, the skin of a hairless rat was mounted in a Franz diffusion cell system and rolled with a disk roller without microneedles and with rollers fitted with microneedles of each size. Rhodamine B base (80 μl) was applied to the skin for 24 hours, 48 hours, and 72 hours, and dye permeation was detected at 543 nm. Dye binding to the skin was also confirmed using fluorescence microscopy at six hours after the application of rhodamine B.
Results Use of the disk microneedle roller increased the skin penetrance of rhodamine B base in hairless rats in accordance with microneedle length, as assessed using a fluorescence penetration test.
Conclusions Disk microneedle rollers, as designed for the DTS™, can be used for transdermal drug delivery. Microneedles can be selected according to the length appropriate for each application.