Improvement in onychomycosis after initiation of combined antiretroviral therapy


  • Funding: This work was supported by the Comisión de Equidad y Género de la Honorable Cámara de Diputados de las LX y LXI Legislaturas de México, and the Fundación México Vivo.

  • Conflicts of interest: None.

Gustavo Reyes-Terán, MD
Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas
Calzada de Tlalpan 4502
Colonia Sección XVI
CP 14080, Delegación Tlalpan
Mexico City DF


Background  Onychomycosis is frequent in patients with late and advanced HIV disease; immunocompromised patients may develop atypical clinical presentations that can be difficult to control. Current treatment for onychomycosis is based on the prolonged administration of antifungal therapies that may have significant interactions with combined antiretroviral therapy (cART). An improvement in certain HIV-associated opportunistic infections has been associated with initiation of cART.

Objectives  The aim of this study was to analyze the influence of cART on the outcome of onychomycosis in HIV-infected patients.

Methods  HIV-infected patients with dermatologic lesions attending the National Institute of Respiratory Diseases were asked to undergo physical examination. Detailed clinical histories were recorded. Routine laboratory tests, CD4 T cell count, and HIV viral load were performed. Onychomycosis was diagnosed on the basis of clinical appearance. Nail scrapings were collected from toenails and fingernails. Specimens were analyzed using direct microscopy. Nail changes after cART initiation were assessed by clinical examination.

Results  Improvement in onychomycosis was observed in six patients with late and advanced HIV disease after initiation of cART. Complete resolution of onychomycosis was observed in one patient without the use of antifungal therapy; one patient required topical antifungal treatment, and two patients required systemic antifungal treatment to achieve complete resolution.

Conclusions  Onychomycosis should be included in the group of pathologies that improve with cART-induced immune reconstitution. The pathogenesis of onychomycosis in HIV disease warrants investigation in the context of cell-mediated immunity restoration.