Conflicts of interests: At the time this study was carried out, AL was a shareholder and Director, and AD was an employee, of Oxford Outcomes Ltd. NB and FJ are employees of Janssen Ortho Inc.
Economic burden of moderate to severe plaque psoriasis in Canada
Article first published online: 21 NOV 2012
© 2012 The International Society of Dermatology
International Journal of Dermatology
Volume 51, Issue 12, pages 1432–1440, December 2012
How to Cite
Levy, A. R., Davie, A. M., Brazier, N. C., Jivraj, F., Albrecht, L. E., Gratton, D. and Lynde, C. W. (2012), Economic burden of moderate to severe plaque psoriasis in Canada. International Journal of Dermatology, 51: 1432–1440. doi: 10.1111/j.1365-4632.2011.05359.x
- Issue published online: 21 NOV 2012
- Article first published online: 21 NOV 2012
Background Psoriasis is a chronic debilitating disease affecting approximately one million Canadians. The objective of this study is to estimate the economic burden in $CDN (2008) of moderate to severe plaque psoriasis among Canadian adults.
Methods Using a cross-sectional design, direct resource use, costs, lost productivity, and quality of life were obtained for 90 subjects diagnosed with psoriasis in three dermatology clinics in British Columbia, Ontario, and Québec. An Excel-based economic model was developed to project the annual cost of psoriasis, from the societal perspective.
Results The estimated mean annual cost of psoriasis was $7999/subject (95% CI: $3563–$12,434) with direct costs accounting for 57%. Mean lost productivity costs, which accounted for 43% of the mean annual costs of psoriasis, were $3442/subject (95% CI: $1293–$5590).
Conclusion Projecting the mean costs per patient to the afflicted population yields an estimated total annual cost of $1.7 billion (95% CI: $0.8–$2.6 billion) attributable to moderate to severe psoriasis in Canada. Understanding the interplay between direct costs, lost productivity, and quality of life is critical for accurately identifying and evaluating effective treatments for this disease.