Associated pyoderma gangrenosum, erythema elevatum diutinum, and Sweet’s syndrome: the concept of neutrophilic disease
Article first published online: 23 SEP 2013
© 2013 The International Society of Dermatology
International Journal of Dermatology
Volume 52, Issue 10, pages 1185–1188, October 2013
How to Cite
Caucanas, M., Heylen, A., Rolland, F., Müller, G., Olemans, C., Sass, U. and Vanhooteghem, O. (2013), Associated pyoderma gangrenosum, erythema elevatum diutinum, and Sweet’s syndrome: the concept of neutrophilic disease. International Journal of Dermatology, 52: 1185–1188. doi: 10.1111/j.1365-4632.2011.05415.x
Conflicts of interest: None.
- Issue published online: 23 SEP 2013
- Article first published online: 23 SEP 2013
Background The association of three neutrophilic dermatoses supports the concept of “neutrophilic disease” as a syndrome representing a continuous spectrum of clinical entities.
Results This report describes three neutrophilic pathologies arising in the same patient, in association with seronegative rheumatoid arthritis. The successive occurrence of erythema elevatum diutinum, pyoderma gangrenosum, and Sweet’s syndrome illustrates the concept of “neutrophilic disease” developed by Wallach et al. in the 1990s. Most authors agree that neutrophilic dermatosis is defined as a cutaneous disease mainly characterized by polymorphonuclear neutrophil infiltration without infectious cause.The assessment of neutrophilic dermatosis includes identification of the type of cutaneous lesion, the existence of possible extracutaneous sites, and a search for associated disease.
Conclusions The occurrence of three separate neutrophilic dermatoses in a single patient lends further support to the concept that these entities form a spectrum of diseases called neutrophilic disease.