Influence of narrowband UVB irradiation of serum on autologous serum skin test results
Article first published online: 8 JUL 2013
© 2013 The International Society of Dermatology
International Journal of Dermatology
Volume 52, Issue 9, pages 1088–1091, September 2013
How to Cite
Kaar, N., Taşli, L., Şanlı, B. and Topsakal, M. (2013), Influence of narrowband UVB irradiation of serum on autologous serum skin test results. International Journal of Dermatology, 52: 1088–1091. doi: 10.1111/j.1365-4632.2012.05511.x
- Issue published online: 21 AUG 2013
- Article first published online: 8 JUL 2013
Vol. 52, Issue 10, 1293, Article first published online: 23 SEP 2013
Background Autologous serum skin test (ASST) is an in vivo test to demonstrate circulating endogenous proinflammatory or wheal-inducing factors in urticaria patients. While ASST was negative in a patient with solar urticaria and in a patient with localized heat urticaria, test results turned to positive when performed with visible light-irradiated and heated serums, respectively. These data suggest that some factors and/or antibodies in serum may be activated or inhibited with different factors. We aimed to investigate whether or not ASST results change when performed with narrowband ultraviolet B (UVB)-irradiated serum.
Materials and methods Seventy-seven patients with chronic idiopathic urticaria underwent ASST twice in consecutive days. The second ASST was performed with narrowband UVB-irradiated serum. The results of the first and second ASSTs were compared.
Results The first ASST results were positive in 46 (59.7%) patients. ASST results reversed oppositely in 36 (46.8%) patients, turned from negative to positive in 19 patients, and turned from positive to negative in 17 patients when performed with narrowband UVB-irradiated serum.
Conclusion Our results suggest that narrowband UVB may have modifying effects on some wheal-inducing factors and/or antibodies. On which factors in serum narrowband UVB has effects may be investigated.