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Family-based association study in Tunisian familial psoriasis

Authors

  • Myriam Ammar PhD,

    1. Laboratory of Genetic, Immunology and Human Pathologies, Department of Biology, Faculty of Sciences, Tunis, Tunisia, Department of Dermatology, La Rabta Hospital, Tunis, Tunisia, Department of Dermatology, Military Hospital of Tunis, Tunis, Tunisia, Department of Human Genetics, Washington University – Saint Louis, USA
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  • Chiraz Bouchlaka-Souissi PhD,

    1. Laboratory of Genetic, Immunology and Human Pathologies, Department of Biology, Faculty of Sciences, Tunis, Tunisia, Department of Dermatology, La Rabta Hospital, Tunis, Tunisia, Department of Dermatology, Military Hospital of Tunis, Tunis, Tunisia, Department of Human Genetics, Washington University – Saint Louis, USA
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  • Ines Zaraa MSc,

    1. Laboratory of Genetic, Immunology and Human Pathologies, Department of Biology, Faculty of Sciences, Tunis, Tunisia, Department of Dermatology, La Rabta Hospital, Tunis, Tunisia, Department of Dermatology, Military Hospital of Tunis, Tunis, Tunisia, Department of Human Genetics, Washington University – Saint Louis, USA
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  • Cindy Helms PhD,

    1. Laboratory of Genetic, Immunology and Human Pathologies, Department of Biology, Faculty of Sciences, Tunis, Tunisia, Department of Dermatology, La Rabta Hospital, Tunis, Tunisia, Department of Dermatology, Military Hospital of Tunis, Tunis, Tunisia, Department of Human Genetics, Washington University – Saint Louis, USA
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  • Nejib Doss MSc,

    1. Laboratory of Genetic, Immunology and Human Pathologies, Department of Biology, Faculty of Sciences, Tunis, Tunisia, Department of Dermatology, La Rabta Hospital, Tunis, Tunisia, Department of Dermatology, Military Hospital of Tunis, Tunis, Tunisia, Department of Human Genetics, Washington University – Saint Louis, USA
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  • Fatma Bouazizi,

    1. Laboratory of Genetic, Immunology and Human Pathologies, Department of Biology, Faculty of Sciences, Tunis, Tunisia, Department of Dermatology, La Rabta Hospital, Tunis, Tunisia, Department of Dermatology, Military Hospital of Tunis, Tunis, Tunisia, Department of Human Genetics, Washington University – Saint Louis, USA
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  • Raouf Dhaoui MSc,

    1. Laboratory of Genetic, Immunology and Human Pathologies, Department of Biology, Faculty of Sciences, Tunis, Tunisia, Department of Dermatology, La Rabta Hospital, Tunis, Tunisia, Department of Dermatology, Military Hospital of Tunis, Tunis, Tunisia, Department of Human Genetics, Washington University – Saint Louis, USA
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  • Amel Ben Ossman MSc,

    1. Laboratory of Genetic, Immunology and Human Pathologies, Department of Biology, Faculty of Sciences, Tunis, Tunisia, Department of Dermatology, La Rabta Hospital, Tunis, Tunisia, Department of Dermatology, Military Hospital of Tunis, Tunis, Tunisia, Department of Human Genetics, Washington University – Saint Louis, USA
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  • Amel Ben Ammar-el Gaied PhD,

    1. Laboratory of Genetic, Immunology and Human Pathologies, Department of Biology, Faculty of Sciences, Tunis, Tunisia, Department of Dermatology, La Rabta Hospital, Tunis, Tunisia, Department of Dermatology, Military Hospital of Tunis, Tunis, Tunisia, Department of Human Genetics, Washington University – Saint Louis, USA
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  • Mourad Mokni MSc

    1. Laboratory of Genetic, Immunology and Human Pathologies, Department of Biology, Faculty of Sciences, Tunis, Tunisia, Department of Dermatology, La Rabta Hospital, Tunis, Tunisia, Department of Dermatology, Military Hospital of Tunis, Tunis, Tunisia, Department of Human Genetics, Washington University – Saint Louis, USA
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  • Conflicts of interest: This is to certify that we have reviewed the manuscript entitled “Family based association study in Tunisian familial psoriasis”, we agree with its contents, we have contributed significantly to the work and we approve of its submission to International Journal of Dermatology for publication considerations. We state that the manuscript we are submitting is not published elsewhere, and is not under consideration elsewhere. All the listed authors have agreed to the submission of the manuscript in its current form. We have no commercial affiliations, consultancies, stock or equity interests, and patent-licensing arrangements that could be considered to pose a conflict of interest regarding the submitted article. We state that we have the approval of Bowcock et al. to publish these results.

Dr. Ammar Myriam
Laboratory of Genetic, Immunology and Human Pathologies
Department of Biology Faculty of Sciences of Tunis, 2092 Tunisia
E-mail: myriambensaid@yahoo.fr

Abstract

Background  The pathogenesis of all forms of psoriasis remains obscure. Segregation analysis and twin studies together with ethnic differences in disease frequency all point to an underlying genetic susceptibility to psoriasis, which is both complex and likely to reflect the action of a number of genes.

Materials and methods  In the present study, we performed a family-based association study, and a transmission dysequilibrium test using the PLINK program, in a set of seven Tunisian multiplex families using a panel of 96 single-nucleotide polymorphisms localized in several regions across the genome. Ninety-five of them were reported to be associated with psoriasis in different populations.

Results  Besides the confirmation of association between previous associated regions: 6p, 1p, 2p, 13q, 14q, and 20p, and cutaneous psoriasis, we identified a new association with the rs1249564 in the IL17RD gene.

Conclusion  Our results support the complex genetic basis of psoriasis.

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