Funding: This work was supported in part by the Animal Technology Institute Taiwan, Miaoli, Taiwan.
Pharmacology and therapeutics
Dermal delivery by niosomes of black tea extract as a sunscreen agent
Article first published online: 22 AUG 2012
© 2012 The International Society of Dermatology
International Journal of Dermatology
Volume 52, Issue 2, pages 239–245, February 2013
How to Cite
Yeh, M.-I., Huang, H.-C., Liaw, J.-H., Huang, M.-C., Huang, K.-F. and Hsu, F.-L. (2013), Dermal delivery by niosomes of black tea extract as a sunscreen agent. International Journal of Dermatology, 52: 239–245. doi: 10.1111/j.1365-4632.2012.05587.x
Conflicts of interest: None.
- Issue published online: 24 JAN 2013
- Article first published online: 22 AUG 2012
Objectives The primary objective of this study was to investigate the feasibility of using niosomes as a delivery vehicle for the dermal administration in vitro of black tea extract (BTE) as a sunscreen.
Methods Multi-lamellar niosomes were obtained by means of a previously reported method of lipid hydration films. In vitro penetration experiments through nude mouse skin were carried out to evaluate the potential of niosomes as a dermal formulation. The nude mouse skin membrane allowed the effects of penetration with a niosome formulation to be evaluated. Penetration rates of caffeine- and gallic acid-loaded niosomes in a steady state were higher than dispersion in aqueous solutions.
Results For skin permeation, higher transdermal absorption rates were seen with solutions of caffeine and gallic acid.
Conclusions In the near future, BTE as a sunscreen agent will be dermally delivered by niosomes.