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Netherton’s syndrome and lepromatous leprosy: a mere coincidence?

Authors

  • Felipe Ladeira de Oliveira MD,

    1. Section for Sexually Transmitted Diseases and Leprosy, Professor R. D. Azulay Institute of Dermatology, Hospital Santa Casa da Misericórdia, Rio de Janeiro, RJ, Brazil
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  • Bruna Obeica Vasconcellos MD,

    1. Section for Sexually Transmitted Diseases and Leprosy, Professor R. D. Azulay Institute of Dermatology, Hospital Santa Casa da Misericórdia, Rio de Janeiro, RJ, Brazil
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  • Thais Schiavo de Morais MD,

    1. Section for Sexually Transmitted Diseases and Leprosy, Professor R. D. Azulay Institute of Dermatology, Hospital Santa Casa da Misericórdia, Rio de Janeiro, RJ, Brazil
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  • Mayara Brito Nascimento MD,

    1. Section for Sexually Transmitted Diseases and Leprosy, Professor R. D. Azulay Institute of Dermatology, Hospital Santa Casa da Misericórdia, Rio de Janeiro, RJ, Brazil
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  • Renata Teles MD,

    1. Section for Sexually Transmitted Diseases and Leprosy, Professor R. D. Azulay Institute of Dermatology, Hospital Santa Casa da Misericórdia, Rio de Janeiro, RJ, Brazil
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  • José Augusto da Costa Nery MD, PhD,

    1. Section for Sexually Transmitted Diseases and Leprosy, Professor R. D. Azulay Institute of Dermatology, Hospital Santa Casa da Misericórdia, Rio de Janeiro, RJ, Brazil
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  • Marcos José Sumrell Miranda MD,

    1. Section for Sexually Transmitted Diseases and Leprosy, Professor R. D. Azulay Institute of Dermatology, Hospital Santa Casa da Misericórdia, Rio de Janeiro, RJ, Brazil
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  • Luna Azulay-Abulafia MD, PhD

    1. Section for Sexually Transmitted Diseases and Leprosy, Professor R. D. Azulay Institute of Dermatology, Hospital Santa Casa da Misericórdia, Rio de Janeiro, RJ, Brazil
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  • Conflicts of interest: None.

Luna Azulay-Abulafia, md, phd
Avenida Epitacio Pessoa 2664
Apto 902 Bloco 1
Lagoa
RJ CEP 22471-003
Brazil
E-mail:lunaazulay@gmail.com

Abstract

Objectives  Netherton’s syndrome (NS) is a rare autosomal recessive condition, first described in 1958, which involves a complex immunological dysfunction, ichthyosiform dermatitis, and erythroderma, characteristic defects of the hair shaft and atopy. Recurrent bacterial infection in the skin of patients with NS is frequent.

Methods  This paper represents the first case report of leprosy and concurrent NS.

Discussion  This case merits discussion among doctors in endemic and non-endemic areas to evaluate the chronic use of systemic corticosteroids as a risk factor for leprosy. The present patient came from an endemic area of leprosy and was treated chronically with systemic corticosteroids for erythroderma. This treatment, along with the immunodeficiency related to the syndrome and caused by a genetic mutation in SPINK5, may be a facilitating factor for the infection.

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