Funding: This study was supported by a grant (A103017) from the Korea Healthcare Technology Research and Development Project, Ministry of Health and Welfare, South Korea.
Patch test reactions in patients with the additional diagnosis of vitiligo
Article first published online: 13 MAR 2013
© 2013 The International Society of Dermatology
International Journal of Dermatology
Volume 53, Issue 2, pages 187–191, February 2014
How to Cite
Lee, J.-H., Ahn, B.-J., Noh, M. and Lee, A.-Y. (2014), Patch test reactions in patients with the additional diagnosis of vitiligo. International Journal of Dermatology, 53: 187–191. doi: 10.1111/j.1365-4632.2012.05666.x
Conflicts of interest: None.
- Issue published online: 21 JAN 2014
- Article first published online: 13 MAR 2013
- Korea Healthcare Technology Research and Development Project. Grant Number: A103017
- Development Project, Ministry of Health and Welfare
Background Melanocytes involved in vitiligo may have inherent aberrations that make them vulnerable to extracellular insult. Allergic contact dermatitis (ACD) has been implicated in the development and progression of vitiligo. This study was conducted to investigate the association between ACD and vitiligo.
Methods A total of 125 patients with vitiligo, who showed lesions in particular locations, onset at an older age, and/or pre-existing inflammation or pruritus, were included. Patch tests were performed using a Korean standard series. In order to investigate the association between avoidance of allergen and clinical improvement, 43 vitiligo patients who showed positive reactions to the patch test completed a questionnaire administered by telephone and self-assessed the status of their condition using a 10-point scale.
Results A total of 98 (78.4%) of 125 patients with vitiligo showed positive patch test reactions to at least one antigen. Although a limited number of contact allergens may have specific predilection sites, a significant association (P = 0.002, odds ratio 3.06) was found between lesions distributed on the scalp and/or hairline and a positive patch test reaction to paraphenylenediamine (PPD). A positive correlation (P = 0.03) was also detected between avoidance of allergen and improvement of vitiligo lesions.
Conclusions Causative allergens of ACD may play a role in the development and/or aggravation of vitiligo.