Conflicts of interest: None.
Merkel cell carcinoma with sarcomatous differentiation: is it a poor prognostic factor?
Version of Record online: 26 DEC 2012
© 2013 The International Society of Dermatology
International Journal of Dermatology
Volume 52, Issue 1, pages 93–95, January 2013
How to Cite
Gomez-Moyano, E., Vera-Casaño, Á., Sanz-Trelles, A. and Martinez, L. (2013), Merkel cell carcinoma with sarcomatous differentiation: is it a poor prognostic factor?. International Journal of Dermatology, 52: 93–95. doi: 10.1111/j.1365-4632.2012.05675.x
- Issue online: 26 DEC 2012
- Version of Record online: 26 DEC 2012
Background Poor prognostic factors in Merkel cell carcinoma include male sex, advanced stage at diagnosis, large tumor size (>5 mm), diffuse growth pattern, heavy lymphocytic infiltrate, and high mitotic rate. To date only six cases of Merkel cell carcinoma with sarcomatous or pseudosarcomatous differentiation and poor prognosis have been documented.
Methods We present a new case of Merkel cell carcinoma with sarcomatous differentiation.
Results The immunohistochemical staining patterns reflected the morphologic differentiation of the epithelial and sarcomatous pattern. After two months of follow-up, there were no signs of local recurrence or metastases.
Conclusion In all cases of merkelomas with sarcomatous differentiation described to date, lymph node metastases have been found, except in the presented case. However, larger series of cases will be required to determine if sarcomatous differentiation represents another negative prognostic factor.