There are no conflicts of interest.
Tropical medicine rounds
Intermediate/borderline disseminated cutaneous leishmaniasis
Article first published online: 11 DEC 2012
© 2012 The International Society of Dermatology
International Journal of Dermatology
Volume 52, Issue 4, pages 446–455, April 2013
How to Cite
Paniz Mondolfi, A. E., Duffey, G. B., Horton, L. E., Tirado, M., Reyes Jaimes, O., Perez-Alvarez, A. and Zerpa, O. (2013), Intermediate/borderline disseminated cutaneous leishmaniasis. International Journal of Dermatology, 52: 446–455. doi: 10.1111/j.1365-4632.2012.05709.x
- Issue published online: 15 MAR 2013
- Article first published online: 11 DEC 2012
Leishmaniasis is a diverse group of vector-borne diseases caused by a subset of predominantly intracellular protozoal species of the genus Leishmania. Cutaneous disease may be subdivided into localized, intermediate, and diffuse forms. Intermediate cutaneous leishmaniasis is distributed widely in Latin America and is characterized by cutaneous lesions, which may be accompanied by mucosal disease and demonstrate a tendency toward chronicity and relapse as well as resistance to standard treatment regimens. Leishmania parasites of the subgenus Viannia have been identified as the major etiologic agent of this subset of infections. The present review provides a brief perspective on leishmaniasis followed by a review of classification, transmission, clinical presentation, and evolution of disease, immunology, and current treatment approaches for the intermediate/borderline disseminated subset of cutaneous leishmaniasis.