Conflicts of interest: None.
Pharmacology and therapeutics
Treatment of a relapsing facial pyoderma gangrenosum (malignant pyoderma)
Article first published online: 20 JAN 2013
© 2013 The International Society of Dermatology
International Journal of Dermatology
Volume 52, Issue 6, pages 753–756, June 2013
How to Cite
Mantovani, L., Zauli, S., Sarno, O., Querzoli, P., Corazza, M. and Virgili, A. (2013), Treatment of a relapsing facial pyoderma gangrenosum (malignant pyoderma). International Journal of Dermatology, 52: 753–756. doi: 10.1111/j.1365-4632.2012.05755.x
- Issue published online: 17 MAY 2013
- Article first published online: 20 JAN 2013
A case of rapidly relapsing pyoderma gangrenosum (PG) of the left preauricular area with no undermined borders is described. This might be considered a case of malignant pyoderma (PM), a rare variety of PG. Five months after complete healing obtained with systemic corticosteroids, the preauricular lesion of PG relapsed. As retreatment with oral methylprednisolone induced glucose intolerance and high arterial pressure, sulfa drugs were initially employed with a transitory recovery of the skin lesion. A successive prolonged course with minocycline induced a new complete resolution. To date, at six months' follow-up, the patient is relapse-free. This case confirms that sulfa drugs and minocycline may also be considered alternative therapies in PM. PM is a variety of PG characterized by specific morphological features, a higher tendency to relapse, and poor responsiveness to treatment.