Funding: This study was supported by the Ministry of Science, Education and Sports of the Republic of Croatia (grant no. 219-2190372-2068).
Meta-analysis of vitamin D receptor polymorphisms and psoriasis risk
Article first published online: 13 MAR 2013
© 2013 The International Society of Dermatology
International Journal of Dermatology
Volume 52, Issue 6, pages 705–710, June 2013
How to Cite
Stefanic, M., Rucevic, I. and Barisic-Drusko, V. (2013), Meta-analysis of vitamin D receptor polymorphisms and psoriasis risk. International Journal of Dermatology, 52: 705–710. doi: 10.1111/j.1365-4632.2012.5813.x
Conflicts of interest: None.
- Issue published online: 17 MAY 2013
- Article first published online: 13 MAR 2013
- Ministry of Science, Education and Sports . Grant Number: 219-2190372-2068
Vitamin D receptor (VDR) gene polymorphisms have been studied as candidate variants that affect psoriasis risk. However, results have been conflicting.
We reviewed studies on VDR polymorphisms and psoriasis risk published to October 1, 2011, and quantitatively summarized associations of the most widely studied variants (FokI, TaqI, ApaI, BsmI) using meta-analysis. Associations were measured using random-effect odds ratios (ORs) combined with 95% confidence intervals (CIs).
Eleven eligible studies, encompassing 1106 cases and 1209 controls, were retrieved from electronic databases and included in this review. The results were heterogeneous, which may be partly explained by small sample bias, the phenomenon of winner's curse, and differences among populations. For FokI and ApaI polymorphisms, we did not find any evidence of association. A borderline allelic association was found for the BsmI B variant after exclusion of the earliest significant report (OR = 0.81, 95% CI 0.68–0.98; P = 0.04, inconsistency index [I 2] = 12.7%). Among Caucasian subjects, the TaqI t allele was nominally associated with psoriasis risk (OR = 0.77, 95% CI 0.64–0.97; P = 0.012, I 2 = 0), with homozygous carriers (tt vs. TT, OR = 0.59, 95% CI 0.39–0.90; P = 0.01, I 2 = 0) and recessive model (tt vs. Tt + TT, OR = 0.66, 95% CI 0.44–0.98; P = 0.04, I 2 = 0) as protective factors. None of these associations persisted after adjustment for multiple comparisons. No publication bias was detected in this meta-analysis.
No genetic variant examined in the VDR gene showed a robust and reproducible association with risk for psoriasis. Any association that may exist is likely to be weak and potentially restricted to specific populations.