Meta-analysis of vitamin D receptor polymorphisms and psoriasis risk


  • Funding: This study was supported by the Ministry of Science, Education and Sports of the Republic of Croatia (grant no. 219-2190372-2068).
  • Conflicts of interest: None.


Mario Stefanic, md, PhD

Clinical Institute of Nuclear Medicine and Radiation Protection

Osijek University Hospital

J. Huttlera 4

31 000 Osijek





Vitamin D receptor (VDR) gene polymorphisms have been studied as candidate variants that affect psoriasis risk. However, results have been conflicting.


We reviewed studies on VDR polymorphisms and psoriasis risk published to October 1, 2011, and quantitatively summarized associations of the most widely studied variants (FokI, TaqI, ApaI, BsmI) using meta-analysis. Associations were measured using random-effect odds ratios (ORs) combined with 95% confidence intervals (CIs).


Eleven eligible studies, encompassing 1106 cases and 1209 controls, were retrieved from electronic databases and included in this review. The results were heterogeneous, which may be partly explained by small sample bias, the phenomenon of winner's curse, and differences among populations. For FokI and ApaI polymorphisms, we did not find any evidence of association. A borderline allelic association was found for the BsmI B variant after exclusion of the earliest significant report (OR = 0.81, 95% CI 0.68–0.98; P = 0.04, inconsistency index [I 2] = 12.7%). Among Caucasian subjects, the TaqI t allele was nominally associated with psoriasis risk (OR = 0.77, 95% CI 0.64–0.97; P = 0.012, I 2 = 0), with homozygous carriers (tt vs. TT, OR = 0.59, 95% CI 0.39–0.90; P = 0.01, I 2 = 0) and recessive model (tt vs. Tt + TT, OR = 0.66, 95% CI 0.44–0.98; P = 0.04, I 2 = 0) as protective factors. None of these associations persisted after adjustment for multiple comparisons. No publication bias was detected in this meta-analysis.


No genetic variant examined in the VDR gene showed a robust and reproducible association with risk for psoriasis. Any association that may exist is likely to be weak and potentially restricted to specific populations.