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Cardioprotective and other emerging effects of statins
Article first published online: 27 SEP 2004
DOI: 10.1111/j.1368-504X.2004.00391.x
Issue
1742-1241/asset/cover.gif?v=1&s=740a8b20db2ff688b9363b499328361fb8bb0aac "International Journal of Clinical Practice")
International Journal of Clinical Practice
Volume 58, Issue Supplement s143, pages 49–57, October 2004
Additional Information
How to Cite
Davignon, J. (2004), Cardioprotective and other emerging effects of statins. International Journal of Clinical Practice, 58: 49–57. doi: 10.1111/j.1368-504X.2004.00391.x
Publication History
- Issue published online: 27 SEP 2004
- Article first published online: 27 SEP 2004
- Abstract
- Article
- References
- Cited By
Keywords:
- Atherosclerosis;
- cardioprotection;
- coronary artery disease;
- inflammation;
- pleiotropic effects;
- statins
Summary
The lipid-lowering properties of statins are accompanied by a number of other cardioprotective effects. These ‘pleiotropic’ actions affect almost the entire process of atherogenesis, from initial endothelial injury to the moment of plaque rupture and thrombosis. This paper discusses the nonlipid-lowering effects of statins that affect the initiation, progression, regression and repair of atherosclerosis lesions, as well as factors that affect plaque instability. The emergent anti-inflammatory, antioxidant and immunomodulatory properties of statins are extensive and diverse. Many of these properties, which are independent of cholesterol synthesis inhibition, help to reduce the ischaemic burden on the cardiovascular system. In addition, the immunomodulatory properties of statins may provide new indications for these agents in the treatment of autoimmune diseases.