BRIEF REPORT: No association of alcohol dependence with SLC6A5 and SLC6A9 glycine transporter polymorphisms

  1. Gabriele Koller1,*,
  2. Peter Zill1,
  3. Christoph Fehr2,
  4. Oliver Pogarell1,
  5. Brigitta Bondy1,
  6. Michael Soyka3,†,
  7. Ulrich-Wilkelm Preuss4,†

Article first published online: 24 JUL 2009

DOI: 10.1111/j.1369-1600.2009.00170.x

Issue

Addiction Biology

Addiction Biology

Volume 14, Issue 4, pages 506–508, October 2009

Additional Information

How to Cite

Koller, G., Zill, P., Fehr, C., Pogarell, O., Bondy, B., Soyka, M. and Preuss, U.-W. (2009), BRIEF REPORT: No association of alcohol dependence with SLC6A5 and SLC6A9 glycine transporter polymorphisms. Addiction Biology, 14: 506–508. doi: 10.1111/j.1369-1600.2009.00170.x

Author Information

  1. 1

    Psychiatrische Klinik/Nußbaumstraße 7/80336 Munich,

  2. 2

    Klinik für Psychiatrie/Untere Zahlbacher Str. 8/55131 Mainz,

  3. 3

    Privatklinik Meiringen/Willigen/CH-3860 Meiringen and

  4. 4

    Klinik für Psychiatrie Martin-Luther-Universität Halle/Julius-Kühn-Straße 7/06097 Halle/Saale, Germany

  1. †

    Both authors contributed equally.

*Gabriele Koller, Psychiatrische Klinik/Nußbaumstraße 7/80336 Munich, Germany. E-mail: gabi.koller@med.uni-muenchen.de

Publication History

  1. Issue published online: 8 SEP 2009
  2. Article first published online: 24 JUL 2009

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Keywords:

  • Alcoholism;
  • association;
  • glycine transporter;
  • haplotype analysis;
  • SLC6A5;
  • SLC6A9

ABSTRACT

To determine whether glycine transporter polymorphisms are associated with alcoholism, three genetic variants of SLC6A5 and two polymorphisms of SLC6A9 were genotyped in 463 German non-alcoholic controls and 644 German alcohol-dependent subjects. Association was investigated employing chi-square statistics and haplotype analysis. There was a significant association between the SLC6A5 polymorphism (rs1443547) and alcohol dependence as alcoholic individuals had a lower rate of AG-allele (χ2 = 6.048, P = 0.049, d.f. = 2), which did not remain significant after correction for multiple testing. There was no association between SLC6A9 glycine transporter polymorphisms and alcohol dependence, and also none in haplotype analysis.

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