Both authors contributed equally.
HUMAN GENETIC STUDY
Epigenetic down regulation of nerve growth factor during alcohol withdrawal
Article first published online: 11 MAR 2011
© 2011 The Authors, Addiction Biology © 2011 Society for the Study of Addiction
Volume 18, Issue 3, pages 508–510, May 2013
How to Cite
Heberlein, A., Muschler, M., Frieling, H., Behr, M., Eberlein, C., Wilhelm, J., Gröschl, M., Kornhuber, J., Bleich, S. and Hillemacher, T. (2013), Epigenetic down regulation of nerve growth factor during alcohol withdrawal. Addiction Biology, 18: 508–510. doi: 10.1111/j.1369-1600.2010.00307.x
- Issue published online: 9 APR 2013
- Article first published online: 11 MAR 2011
- Alcohol withdrawal;
- epigenetic regulation;
- nerve growth factor;
We investigated the Cytosin-phosphatidyl-Guanin (CpG) island promoter methylation (mean and methylation of individual CpG-sites) of the nerve growth factor (NGF) gene in the blood of alcohol-dependent patients (57 male patients) during withdrawal (days 1, 7 and 14). Methylation and NGF serum levels did not change significantly from days 1–7. From days 7–14, mean methylation increased (F = 30.55, P < 0.001), whereas the NGF serum levels decreased significantly (days 7–14: F = 17.95, P < 0.001). The NGF serum levels were significantly associated with the mean methylation of the investigated CpG-sites (F = 1.55, P < 0.001). These results imply an epigenetic regulation of the NGF gene during alcohol withdrawal.