These authors cooperated equally.
Association between a polymorphism in the promoter of a glutamate receptor subunit gene (GRIN2A) and alcoholism
Article first published online: 20 APR 2011
© 2011 The Authors, Addiction Biology © 2011 Society for the Study of Addiction
Volume 17, Issue 4, pages 783–785, July 2012
How to Cite
Domart, M.-C., Benyamina, A., Lemoine, A., Bourgain, C., Blecha, L., Debuire, B., Reynaud, M. and Saffroy, R. (2012), Association between a polymorphism in the promoter of a glutamate receptor subunit gene (GRIN2A) and alcoholism. Addiction Biology, 17: 783–785. doi: 10.1111/j.1369-1600.2011.00321.x
- Issue published online: 2 JUL 2012
- Article first published online: 20 APR 2011
- (GT)n repeat
A variable (GT)n repeat in the 5′-regulatory region of N-methyl-D-aspartate GRIN2A subtype has recently been identified and associated with psychiatric disorders. In this study, we examined the association of this polymorphism with alcohol dependence. Subject–control analysis included 206 alcohol-dependent and 168 control subjects. Average observed repeat numbers and genotype distributions were significantly different (P-value = 0.001) in alcohol-dependent subjects versus control subjects. Short alleles were significantly less frequent among alcohol-dependent subjects (odds ratio = 0.58, P-value = 7 × 10−4). These results could be replicated in an independent sample of 116 alcohol-dependent subjects. For the first time, a significant association was identified between this polymorphism and alcoholism.