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Association between a polymorphism in the promoter of a glutamate receptor subunit gene (GRIN2A) and alcoholism

Authors

  • Marie-Charlotte Domart,

    1. Laboratoire de Biochimie et Biologie moléculaire, AP-HP, Hôpital Paul Brousse, Université Paris 11, Inserm U1004, IFR89 Villejuif, France
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  • Amine Benyamina,

    1. Service d'Addictologie, AP-HP, Hôpital Paul Brousse, Villejuif, France
    2. Inserm U669, Villejuif, France
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  • Antoinette Lemoine,

    1. Laboratoire de Biochimie et Biologie moléculaire, AP-HP, Hôpital Paul Brousse, Université Paris 11, Inserm U1004, IFR89 Villejuif, France
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  • Catherine Bourgain,

    1. Inserm U669, Villejuif, France
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  • Lisa Blecha,

    1. Service d'Addictologie, AP-HP, Hôpital Paul Brousse, Villejuif, France
    2. Inserm U669, Villejuif, France
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  • Brigitte Debuire,

    1. Laboratoire de Biochimie et Biologie moléculaire, AP-HP, Hôpital Paul Brousse, Université Paris 11, Inserm U1004, IFR89 Villejuif, France
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  • Michel Reynaud,

    1. Service d'Addictologie, AP-HP, Hôpital Paul Brousse, Villejuif, France
    2. Inserm U669, Villejuif, France
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    • These authors cooperated equally.

  • Raphaël Saffroy

    Corresponding author
    1. Laboratoire de Biochimie et Biologie moléculaire, AP-HP, Hôpital Paul Brousse, Université Paris 11, Inserm U1004, IFR89 Villejuif, France
      Raphaël Saffroy, Laboratoire de Biochimie Biologie moléculaire, Hôpital Paul Brousse, 14 avenue Paul Vaillant Couturier 94800 Villejuif, France. E-mail: raphael.saffroy@pbr.aphp.fr
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    • These authors cooperated equally.


Raphaël Saffroy, Laboratoire de Biochimie Biologie moléculaire, Hôpital Paul Brousse, 14 avenue Paul Vaillant Couturier 94800 Villejuif, France. E-mail: raphael.saffroy@pbr.aphp.fr

ABSTRACT

A variable (GT)n repeat in the 5′-regulatory region of N-methyl-D-aspartate GRIN2A subtype has recently been identified and associated with psychiatric disorders. In this study, we examined the association of this polymorphism with alcohol dependence. Subject–control analysis included 206 alcohol-dependent and 168 control subjects. Average observed repeat numbers and genotype distributions were significantly different (P-value = 0.001) in alcohol-dependent subjects versus control subjects. Short alleles were significantly less frequent among alcohol-dependent subjects (odds ratio = 0.58, P-value = 7 × 10−4). These results could be replicated in an independent sample of 116 alcohol-dependent subjects. For the first time, a significant association was identified between this polymorphism and alcoholism.

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