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Figure S1 Correlation between trough methadone plasma levels and daily methadone doses.

Figure S2 Structure analysis of the sample anchored to 1051 subjects (HGDP-CEPH) as reference, using 4 clusters correspond to Africa, Europe, Middle East and Asia.

Figure S3 Pair-wise LD analysis between SNPs in CYP2B6 and CYP2D6.

Table Sl Primers sequences.

Table S2 Sample data.

Table S3 Biographical Ancestry Scores based on Structure analysis of AIMs data.

Table S4 SNPs not variable in the study sample.

Table S5 Individual SNP association analysis with methadone daily doses.

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