Chronic cocaine self-administration modulates ERK1/2 and CREB responses to dopamine receptor agonists in striatal slices
Article first published online: 4 AUG 2011
© 2011 The Authors, Addiction Biology © 2011 Society for the Study of Addiction
Volume 17, Issue 3, pages 565–575, May 2012
How to Cite
Hoffmann, H. M., Nadal, R., Vignes, M. and Ortiz, J. (2012), Chronic cocaine self-administration modulates ERK1/2 and CREB responses to dopamine receptor agonists in striatal slices. Addiction Biology, 17: 565–575. doi: 10.1111/j.1369-1600.2011.00353.x
- Issue published online: 19 APR 2012
- Article first published online: 4 AUG 2011
Figure S1 Identification of rats with a low and high intake of cocaine in a fixed ratio cocaine self-administration paradigm.
Figure S2 Time courses of SKF38393-induced ERK1/2 and CREB phosphorylations in striatal slices obtained from naïve rats.
Figure S3 Dopamine D1 receptor-mediated CREB activation was ERK1/2 dependent in slices from the dorsal striatum of naïve rats.
Figure S4 Dopamine D2 receptor activation elicited ERK1/2 and CREB phosphorylation in the striatum but not in the nucleus accumbens NAc of naïve rats.
Figure S5 Tissue slicing-induced ERK1/2 phosphorylation.
Figure S6 D1R and D2R activation lead to ERK1/2 and CREB phosphorylation at 5 and 10 minutes.
Figure S7 A lower concentration (100 nM) of SKF38393 elicited ERK1/2 and CREB phosphorylations in slices from sham and chronic cocaine self-administration rats.
Figure S8 Weights of rats used at the several time points of the study.
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