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Figure S1 Identification of rats with a low and high intake of cocaine in a fixed ratio cocaine self-administration paradigm.

Figure S2 Time courses of SKF38393-induced ERK1/2 and CREB phosphorylations in striatal slices obtained from naïve rats.

Figure S3 Dopamine D1 receptor-mediated CREB activation was ERK1/2 dependent in slices from the dorsal striatum of naïve rats.

Figure S4 Dopamine D2 receptor activation elicited ERK1/2 and CREB phosphorylation in the striatum but not in the nucleus accumbens NAc of naïve rats.

Figure S5 Tissue slicing-induced ERK1/2 phosphorylation.

Figure S6 D1R and D2R activation lead to ERK1/2 and CREB phosphorylation at 5 and 10 minutes.

Figure S7 A lower concentration (100 nM) of SKF38393 elicited ERK1/2 and CREB phosphorylations in slices from sham and chronic cocaine self-administration rats.

Figure S8 Weights of rats used at the several time points of the study.

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