HUMAN MOLECULAR STUDY
The endogenous opioid system in human alcoholics: molecular adaptations in brain areas involved in cognitive control of addiction
Article first published online: 28 SEP 2011
© 2011 The Authors, Addiction Biology © 2011 Society for the Study of Addiction
Volume 18, Issue 1, pages 161–169, January 2013
How to Cite
Bazov, I., Kononenko, O., Watanabe, H., Kuntić, V., Sarkisyan, D., Taqi, M. M., Hussain, M. Z., Nyberg, F., Yakovleva, T. and Bakalkin, G. (2013), The endogenous opioid system in human alcoholics: molecular adaptations in brain areas involved in cognitive control of addiction. Addiction Biology, 18: 161–169. doi: 10.1111/j.1369-1600.2011.00366.x
- Issue published online: 25 DEC 2012
- Article first published online: 28 SEP 2011
Figure S1 Correlations between age and PDYN mRNA (a), dynorphin A (b), dynorphin B (c) levels in the dl-PFC, OPRK1 mRNA (d) in OFC, dynorphin A (e) and dynorphin B (f) levels in hippocampus (HP). R values are shown, P > 0.05 for all correlations. r and P values for these correlations are also shown in Supporting Information Table S4.
Table S1 Demographic data of alcoholics and control subjects.
Table S2 TaqMan® Gene Expression Assays used in analysis of EOS gene expression.
Table S3 Pearson correlations between levels of dynorphin peptides and PMI; correlation coefficient r and P values are shown for pooled control and alcoholic groups (n = 28).
Table S4 Pearson correlations between EOS parameters significantly different between controls and alcoholics, and age; correlation coefficient r and P values are shown for pooled control and alcoholic groups (n = 28).
Table S5 Pearson correlations between levels of PDYN mRNA and dynorphin peptides; correlation coefficient r (in bold) and P values are shown for pooled control and alcoholic groups (n = 28).
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