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Figure S1 Correlations between age and PDYN mRNA (a), dynorphin A (b), dynorphin B (c) levels in the dl-PFC, OPRK1 mRNA (d) in OFC, dynorphin A (e) and dynorphin B (f) levels in hippocampus (HP). R values are shown, P > 0.05 for all correlations. r and P values for these correlations are also shown in Supporting Information Table S4.

Table S1 Demographic data of alcoholics and control subjects.

Table S2 TaqMan® Gene Expression Assays used in analysis of EOS gene expression.

Table S3 Pearson correlations between levels of dynorphin peptides and PMI; correlation coefficient r and P values are shown for pooled control and alcoholic groups (n = 28).

Table S4 Pearson correlations between EOS parameters significantly different between controls and alcoholics, and age; correlation coefficient r and P values are shown for pooled control and alcoholic groups (n = 28).

Table S5 Pearson correlations between levels of PDYN mRNA and dynorphin peptides; correlation coefficient r (in bold) and P values are shown for pooled control and alcoholic groups (n = 28).

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