Get access

Glucocorticoid and polyamine interactions in the plasticity of glutamatergic synapses that contribute to ethanol-associated dependence and neuronal injury


  • Mark A. Prendergast,

    Corresponding author
    1. Department of Psychology and Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY, USA
    Search for more papers by this author
  • Patrick J. Mulholland

    1. Departments of Neurosciences and Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA
    Search for more papers by this author

Mark A. Prendergast, Department of Psychology, Spinal Cord and Brain Injury Research Center, University of Kentucky, B449 Biomedical and Biological Sciences Research Building, 741 South Limestone Street, Lexington, KY 40536, USA. E-mail:


Stress contributes to the development of ethanol dependence and is also a consequence of dependence. However, the complexity of physiological interactions between activation of the hypothalamic–pituitary–adrenal (HPA) axis and ethanol itself is not well delineated. Emerging evidence derived from examination of corticotropin-releasing factor systems and glucocorticoid receptor systems in ethanol dependence suggests a role for pharmacological manipulation of the HPA axis in attenuating ethanol intake, though it is not clear how activation of the HPA axis may promote ethanol dependence or contribute to the neuroadaptative changes that accompany the development of dependence and the severity of ethanol withdrawal. This review examines the role that glucocorticoids, in particular, have in promoting ethanol-associated plasticity of glutamatergic synapses by influencing expression of endogenous linear polyamines and polyamine-sensitive polypeptide subunits of N-methyl-D-aspartate (NMDA)-type glutamate receptors. We provide evidence that interactions among glucocorticoid systems, polyamines and NMDA receptors are highly relevant to both the development of ethanol dependence and to behavioral and neuropathological sequelae associated with ethanol withdrawal. Examination of these issues is likely to be of critical importance not only in further elucidating the neurobiology of HPA axis dysregulation in ethanol dependence, but also with regard to identification of novel therapeutic targets that may be exploited in the treatment of ethanol dependence.