Smoking abstinence and depressive symptoms modulate the executive control system during emotional information processing

Authors

  • Brett Froeliger,

    Corresponding author
    1. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    2. Duke-UNC Brain Imaging and Analysis Center, Durham, NC, USA
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  • Leslie A. Modlin,

    1. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
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  • Rachel V. Kozink,

    1. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    2. Duke-UNC Brain Imaging and Analysis Center, Durham, NC, USA
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  • Lihong Wang,

    1. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    2. Duke-UNC Brain Imaging and Analysis Center, Durham, NC, USA
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  • F. Joseph McClernon

    1. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    2. Duke-UNC Brain Imaging and Analysis Center, Durham, NC, USA
    3. Durham Veterans Affairs Medical Center and VISN 6 Mental Illness Research, Education, and Clinical Center, Durham, NC, USA
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Brett Froeliger, Duke University Medical Center, Box 201, Durham, NC 27705, USA. E-mail: brett.froeliger@duke.edu

ABSTRACT

Smoking abstinence disrupts affective and cognitive processes. In this study, functional magnetic resonance imaging (fMRI) was used to investigate the effects of smoking abstinence on emotional information processing. Smokers (n = 17) and non-smokers (n = 18) underwent fMRI while performing an emotional distractor oddball task in which rare targets were presented following negative and neutral task-irrelevant distractors. Smokers completed two sessions: once following 24-hour abstinence and once while satiated. The abstinent versus satiated states were compared by evaluating responses to distractor images and to targets following each distractor valence within frontal executive and limbic brain regions. Regression analyses were done to investigate whether self-reported negative affect influences brain response to images and targets. Exploratory regression analyses examined relations between baseline depressive symptoms and smoking state on brain function. Smoking state affected response to target detection in the right inferior frontal gyrus (IFG). During satiety, activation was greater in response to targets following negative versus neutral distractors; following abstinence, the reverse was observed. Withdrawal-related negative affect was associated with right insula activation to negative images. Finally, depression symptoms were associated with abstinence-induced hypoactive response to negative emotional distractors and task-relevant targets following negative distractors in frontal brain regions. Neural processes related to novelty detection/attention in the right IFG may be disrupted by smoking abstinence and negative stimuli. Reactivity to emotional stimuli and the interfering effects on cognition are moderated by the magnitude of smoking state-dependent negative affect and baseline depressive symptoms.

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