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Figure S1 Number-guessing task

Figure S2 Time-courses from regions extracted from the Condition × Timepoint interaction effect of the whole-brain ANOVA.

Figure S3 Time-courses from regions extracted from the Condition × Timepoint interaction effect of the whole-brain ANOVA.

Figure S4 Time-courses from regions extracted from the Group × Timepoint interaction effect of the whole-brain ANOVA.

Table S1 Comparison of diagnostic interview measures between never-regular and regular smokers in the entire twin cohort from which MZ twins for neuro-imaging were recruited

Table S2 Smoking behavior from questionnaire data in 15 MZ twin pairs discordant for regular smoking

Table S3 Diagnostic interview measures in the 15 MZ twin pairs discordant for regular smoking

Table S4 Statistical significance and effect size estimations for pairwise comparisons of ventral striatum activation

Table S5 Comparison of average peak percent BOLD change response (4 and 6 seconds post-stimulus) between current and former smokers and between lifetime dependent and non-dependent smokers

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