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Figure S1 Regional cerebral blood flow (rCBF) changes in response to ondansetron relative to saline (P < 0.001) in 22 healthy controls subjects.

Figure S2 Regional cerebral blood flow (rCBF) changes in response to ondansetron relative to saline (P < 0.001) in 10 early-onset subjects.

Figure S3 Regional cerebral blood flow (rCBF) changes in response to ondansetron relative to saline (P < 0.001) in 10 late-onset cocaine-addicted participants.

Figure S4 Differences in regional cerebral blood flow (rCBF) changes in response to ondansetron relative to saline (P < 0.001) in 10 early-onset versus 10 late-onset cocaine-addicted participants.

Figure S5 Differences in regional cerebral blood flow (rCBF) changes in response to ondansetron relative to saline (P < 0.001) in 10 early-onset versus 22 control participants.

Figure S6 Differences in regional cerebral blood flow (rCBF) changes in response to ondansetron relative to saline (P < 0.001) in 10 late-onset versus 22 control participants.

Table S1 Within-group comparison of Subjective Symptom Inventory (SSI) response to saline and ondansetron infusions.

Table S2 Comparison of change in Subjective Symptom Inventory (ΔSSI) between controls, early-onset and late-onset groups.

Table S3 Comparison of change in Subjective Symptom Inventory (ΔSSI) between controls, early-onset and late-onset groups.

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