The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation
Article first published online: 24 JUL 2012
© 2012 The Authors, Addiction Biology © 2012 Society for the Study of Addiction
How to Cite
Verweij, K. J. H., Vinkhuyzen, A. A. E., Benyamin, B., Lynskey, M. T., Quaye, L., Agrawal, A., Gordon, S. D., Montgomery, G. W., Madden, P. A. F., Heath, A. C., Spector, T. D., Martin, N. G. and Medland, S. E. (2012), The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation. Addiction Biology. doi: 10.1111/j.1369-1600.2012.00478.x
- Article first published online: 24 JUL 2012
- National Institutes of Health, Bethesda, Md. Grant Numbers: AA013326, AA014041, AA13320, AA013321, DA23668, DA12854
While initiation of cannabis use is around 40% heritable, not much is known about the underlying genetic aetiology. Here, we meta-analysed two genome-wide association studies of initiation of cannabis use with > 10 000 individuals. None of the genetic variants reached genome-wide significance. We also performed a gene-based association test, which also revealed no significant effects of individual genes. Finally, we estimated that only approximately 6% of the variation in cannabis initiation is due to common genetic variants. Future genetic studies using larger sample sizes and different methodologies (including sequencing) might provide more insight in the complex genetic aetiology of cannabis use.