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A codon 31ser–arg polymorphism of the WAF-1/CIP-1/p21/tumour suppressor gene in Chinese primary open-angle glaucoma

  1. Fuu-Jen Tsai1,
  2. Hui-Ju Lin2,
  3. Wen-Chi Chen1,
  4. Chang-Hai Tsai1,
  5. Shih-Wei Tsai3

Article first published online: 23 JAN 2004

DOI: 10.1111/j.1395-3907.2004.0180.x

Issue

Acta Ophthalmologica Scandinavica

Acta Ophthalmologica Scandinavica

Volume 82, Issue 1, pages 76–80, February 2004

Additional Information

How to Cite

Tsai, F.-J., Lin, H.-J., Chen, W.-C., Tsai, C.-H. and Tsai, S.-W. (2004), A codon 31ser–arg polymorphism of the WAF-1/CIP-1/p21/tumour suppressor gene in Chinese primary open-angle glaucoma. Acta Ophthalmologica Scandinavica, 82: 76–80. doi: 10.1111/j.1395-3907.2004.0180.x

Author Information

  1. 1

    Department of Medical Genetics and Paediatrics, China Medical University Hospital, Taichung, Taiwan

  2. 2

    Department of Ophthalmology, China Medical University Hospital, Taichung, Taiwan

  3. 3

    Department of Occupational Safety and Health, Institute of Environmental Medicine, China Medical University, Taichung, Taiwan

Publication History

  1. Issue published online: 23 JAN 2004
  2. Article first published online: 23 JAN 2004
  3. Received on July 8th, 2003. Accepted on September 23rd, 2003.

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Keywords:

  • p21;
  • genetic polymorphism;
  • glaucoma;
  • WAF-1;
  • CIP-1

Abstract.

Purpose:  Glaucomatous neuropathy is a type of cell death by apoptosis. Apoptosis is a genetically controlled form of cell death, and one of its primary regulatory steps is the activation of the tumour suppressor protein p53, of which p21 is an effector protein. The association between p21 codon 31 polymorphism and primary open-angle glaucoma (POAG) patients was evaluated in this study.

Methods:  The study included 58 POAG patients and a control group of 59 healthy volunteers. Polymerase chain reaction-based analysis was used to resolve the p21 codon 31 polymorphism.

Results:  The genotype frequencies of p21 codon 31 polymorphism were statistically different (p < 0.05) between the two groups. The Arg allele of the p21 codon 31 polymorphism was more frequently found in POAG patients than in healthy individuals (odds ratio: 2.389, 95% confidence interval: 1.14–5.01).

Conclusion:  This study suggests that an association exists between the Arg allele of the p21 codon 31 polymorphism and POAG in the Chinese population.

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