These results were presented in part at the 40th Annual Congress of the American College of Allergists, April 7–11, 1984, San Francisco.
Cytodestructive Mechanisms Provoked by Food Antigens
II. Antibody-Dependent, Allergic Autocytotoxicity*
Article first published online: 28 APR 2007
Volume 40, Issue 3, pages 166–172, April 1985
How to Cite
PODLESKI, W. K. (1985), Cytodestructive Mechanisms Provoked by Food Antigens. Allergy, 40: 166–172. doi: 10.1111/j.1398-9995.1985.tb00212.x
- Issue published online: 28 APR 2007
- Article first published online: 28 APR 2007
- Accepted for publication 8 October 1984
- allergic autocytotoxicity;
- food antibodies;
- food antigens
Antibody-dependent, allergic autocytotoxicity (ACT) is an in vitro process through which WBC from patients and/or controls, passively sensitized with RAST positive serum, are damaged in the presence of corresponding food antigens. Studies among 13 patients, sensitive to cow milk, corn and wheat, and 13 asymptomatic controls revealed that antibody-dependent ACT is mediated by thermolabile cytotoxic factor, presumably IgE antibody. The resultant cellular interactions might contribute to the induction of the autoimmune response.